Ho PC - Search Results

1

Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

Wang LZ, Ramírez J, Yeo W, Chan MY, Thuya WL, Lau JY, Wan SC, Wong AL, Zee YK, Lim R, Lee SC, Ho PC, Lee HS, Chan A, Ansher S, Ratain MJ, Goh BC. Wang LZ, et al. Among authors: ho pc. PLoS One. 2013;8(1):e54522. doi: 10.1371/journal.pone.0054522. Epub 2013 Jan 30. PLoS One. 2013. PMID: 23382909 Free PMC article. Clinical Trial.

2

Rapid determination of gefitinib and its main metabolite, O-desmethyl gefitinib in human plasma using liquid chromatography-tandem mass spectrometry.

Wang LZ, Lim MY, Chin TM, Thuya WL, Nye PL, Wong A, Chan SY, Goh BC, Ho PC. Wang LZ, et al. Among authors: ho pc. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jul 15;879(22):2155-61. doi: 10.1016/j.jchromb.2011.05.056. Epub 2011 Jun 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21703945

3

Method development and validation for rapid quantification of hydroxychloroquine in human blood using liquid chromatography-tandem mass spectrometry.

Wang LZ, Ong RY, Chin TM, Thuya WL, Wan SC, Wong AL, Chan SY, Ho PC, Goh BC. Wang LZ, et al. Among authors: ho pc. J Pharm Biomed Anal. 2012 Mar 5;61:86-92. doi: 10.1016/j.jpba.2011.11.034. Epub 2011 Dec 8. J Pharm Biomed Anal. 2012. PMID: 22197155 Clinical Trial.

4

Validation of a rapid and sensitive LC-MS/MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17-O-β-D-glucuronide: application to human pharmacokinetics study.

Wang LZ, Goh SH, Wong AL, Thuya WL, Lau JY, Wan SC, Lee SC, Ho PC, Goh BC. Wang LZ, et al. Among authors: ho pc. PLoS One. 2015 Mar 20;10(3):e0118553. doi: 10.1371/journal.pone.0118553. eCollection 2015. PLoS One. 2015. PMID: 25793887 Free PMC article.

5

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development.

Wang L, Phan DD, Zhang J, Ong PS, Thuya WL, Soo R, Wong AL, Yong WP, Lee SC, Ho PC, Sethi G, Goh BC. Wang L, et al. Among authors: ho pc. Oncotarget. 2016 Jul 12;7(28):44790-44802. doi: 10.18632/oncotarget.8316. Oncotarget. 2016. PMID: 27027349 Free PMC article. Review.

6

A novel combinatorial strategy using Seliciclib(®) and Belinostat(®) for eradication of non-small cell lung cancer via apoptosis induction and BID activation.

Ong PS, Wang L, Chia DM, Seah JY, Kong LR, Thuya WL, Chinnathambi A, Lau JY, Wong AL, Yong WP, Yang D, Ho PC, Sethi G, Goh BC. Ong PS, et al. Among authors: ho pc. Cancer Lett. 2016 Oct 10;381(1):49-57. doi: 10.1016/j.canlet.2016.07.023. Epub 2016 Jul 25. Cancer Lett. 2016. PMID: 27461583

7

Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1.

Wang L, Chan CEL, Wong AL, Wong FC, Lim SW, Chinnathambi A, Alharbi SA, Lee LS, Soo R, Yong WP, Lee SC, Ho PC, Sethi G, Goh BC. Wang L, et al. Among authors: ho pc. Oncotarget. 2017 Jun 20;8(25):41572-41581. doi: 10.18632/oncotarget.15017. Oncotarget. 2017. PMID: 28157715 Free PMC article.

8

Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling.

Wang L, Syn NL, Subhash VV, Any Y, Thuya WL, Cheow ESH, Kong L, Yu F, Peethala PC, Wong AL, Laljibhai HJ, Chinnathambi A, Ong PS, Ho PC, Sethi G, Yong WP, Goh BC. Wang L, et al. Among authors: ho pc. Cancer Lett. 2018 Mar 28;417:152-160. doi: 10.1016/j.canlet.2017.12.030. Epub 2018 Jan 4. Cancer Lett. 2018. PMID: 29306016

9

A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study.

Wang L, Phan DK, Syn N, Xiang X, Song H, Thuya WL, Yang S, Wong AL, Kumar AP, Yong WP, Sethi G, Ho PC, Goh BC. Wang L, et al. Among authors: ho pc. Pharmaceutics. 2018 Aug 8;10(3):123. doi: 10.3390/pharmaceutics10030123. Pharmaceutics. 2018. PMID: 30096831 Free PMC article.

10

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs.

Wong AL, Xiang X, Ong PS, Mitchell EQY, Syn N, Wee I, Kumar AP, Yong WP, Sethi G, Goh BC, Ho PC, Wang L. Wong AL, et al. Among authors: ho pc. Pharmaceutics. 2018 Nov 8;10(4):221. doi: 10.3390/pharmaceutics10040221. Pharmaceutics. 2018. PMID: 30413076 Free PMC article. Review.

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