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Ordering a dynamic protein via a small-molecule stabilizer.
Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL 3rd, Wells JA, Mapp AK. Wang N, et al. Among authors: sadowsky jd. J Am Chem Soc. 2013 Mar 6;135(9):3363-6. doi: 10.1021/ja3122334. Epub 2013 Feb 22. J Am Chem Soc. 2013. PMID: 23384013 Free PMC article.
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. Rettenmaier TJ, et al. Among authors: sadowsky jd. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17. Proc Natl Acad Sci U S A. 2014. PMID: 25518860 Free PMC article.
On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy.
Adhikari P, Li G, Go M, Mandikian D, Rafidi H, Ng C, Anifa S, Johnson K, Bao L, Hernandez Barry H, Rowntree R, Agard N, Wu C, Chou KJ, Zhang D, Kozak KR, Pillow TH, Lewis GD, Yu SF, Boswell CA, Sadowsky JD. Adhikari P, et al. Among authors: sadowsky jd. J Am Chem Soc. 2024 Jul 17;146(28):19088-19100. doi: 10.1021/jacs.4c03529. Epub 2024 Jul 1. J Am Chem Soc. 2024. PMID: 38946086
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Sadowsky JD, Pillow TH, Chen J, Fan F, He C, Wang Y, Yan G, Yao H, Xu Z, Martin S, Zhang D, Chu P, Dela Cruz-Chuh J, O'Donohue A, Li G, Del Rosario G, He J, Liu L, Ng C, Su D, Lewis Phillips GD, Kozak KR, Yu SF, Xu K, Leipold D, Wai J. Sadowsky JD, et al. Bioconjug Chem. 2017 Aug 16;28(8):2086-2098. doi: 10.1021/acs.bioconjchem.7b00258. Epub 2017 Jul 13. Bioconjug Chem. 2017. PMID: 28636382
31 results