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Design of an Escherichia coli expressed HIV-1 gp120 fragment immunogen that binds to b12 and induces broad and potent neutralizing antibodies.
Bhattacharyya S, Singh P, Rathore U, Purwar M, Wagner D, Arendt H, DeStefano J, LaBranche CC, Montefiori DC, Phogat S, Varadarajan R. Bhattacharyya S, et al. Among authors: destefano j. J Biol Chem. 2013 Apr 5;288(14):9815-9825. doi: 10.1074/jbc.M112.425959. Epub 2013 Feb 21. J Biol Chem. 2013. PMID: 23430741 Free PMC article.
Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes.
Hoffenberg S, Powell R, Carpov A, Wagner D, Wilson A, Kosakovsky Pond S, Lindsay R, Arendt H, Destefano J, Phogat S, Poignard P, Fling SP, Simek M, Labranche C, Montefiori D, Wrin T, Phung P, Burton D, Koff W, King CR, Parks CL, Caulfield MJ. Hoffenberg S, et al. Among authors: destefano j. J Virol. 2013 May;87(10):5372-83. doi: 10.1128/JVI.02827-12. Epub 2013 Mar 6. J Virol. 2013. PMID: 23468492 Free PMC article.
Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies.
Rathore U, Purwar M, Vignesh VS, Das R, Kumar AA, Bhattacharyya S, Arendt H, DeStefano J, Wilson A, Parks C, La Branche CC, Montefiori DC, Varadarajan R. Rathore U, et al. Among authors: destefano j. J Biol Chem. 2018 Sep 28;293(39):15002-15020. doi: 10.1074/jbc.RA118.005006. Epub 2018 Aug 9. J Biol Chem. 2018. PMID: 30093409 Free PMC article.
The stem of vesicular stomatitis virus G can be replaced with the HIV-1 Env membrane-proximal external region without loss of G function or membrane-proximal external region antigenic properties.
Lorenz IC, Nguyen HT, Kemelman M, Lindsay RW, Yuan M, Wright KJ, Arendt H, Back JW, DeStefano J, Hoffenberg S, Morrow G, Jurgens CK, Phogat SK, Zamb TJ, Parks CL. Lorenz IC, et al. Among authors: destefano j. AIDS Res Hum Retroviruses. 2014 Nov;30(11):1130-44. doi: 10.1089/AID.2013.0206. Epub 2014 Apr 9. AIDS Res Hum Retroviruses. 2014. PMID: 24597516 Free PMC article.
Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.
Crooks ET, Tong T, Chakrabarti B, Narayan K, Georgiev IS, Menis S, Huang X, Kulp D, Osawa K, Muranaka J, Stewart-Jones G, Destefano J, O'Dell S, LaBranche C, Robinson JE, Montefiori DC, McKee K, Du SX, Doria-Rose N, Kwong PD, Mascola JR, Zhu P, Schief WR, Wyatt RT, Whalen RG, Binley JM. Crooks ET, et al. Among authors: destefano j. PLoS Pathog. 2015 May 29;11(5):e1004932. doi: 10.1371/journal.ppat.1004932. eCollection 2015 May. PLoS Pathog. 2015. PMID: 26023780 Free PMC article.
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW. de Taeye SW, et al. Among authors: destefano j. Cell. 2015 Dec 17;163(7):1702-15. doi: 10.1016/j.cell.2015.11.056. Cell. 2015. PMID: 26687358 Free PMC article.
A novel, live-attenuated vesicular stomatitis virus vector displaying conformationally intact, functional HIV-1 envelope trimers that elicits potent cellular and humoral responses in mice.
Rabinovich S, Powell RL, Lindsay RW, Yuan M, Carpov A, Wilson A, Lopez M, Coleman JW, Wagner D, Sharma P, Kemelman M, Wright KJ, Seabrook JP, Arendt H, Martinez J, DeStefano J, Chiuchiolo MJ, Parks CL. Rabinovich S, et al. Among authors: destefano j. PLoS One. 2014 Sep 12;9(9):e106597. doi: 10.1371/journal.pone.0106597. eCollection 2014. PLoS One. 2014. PMID: 25215861 Free PMC article.
134 results