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Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels.
Staudacher K, Staudacher I, Ficker E, Seyler C, Gierten J, Kisselbach J, Rahm AK, Trappe K, Schweizer PA, Becker R, Katus HA, Thomas D. Staudacher K, et al. Among authors: schweizer pa. Br J Pharmacol. 2011 Jul;163(5):1099-110. doi: 10.1111/j.1476-5381.2011.01319.x. Br J Pharmacol. 2011. PMID: 21410455 Free PMC article.
Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.
Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D. Jehle J, et al. Among authors: schweizer pa. Br J Pharmacol. 2013 Mar;168(5):1215-29. doi: 10.1111/bph.12002. Br J Pharmacol. 2013. PMID: 23061993 Free PMC article.
Biophysical characterization of KCNQ1 P320 mutations linked to long QT syndrome 1.
Thomas D, Khalil M, Alter M, Schweizer PA, Karle CA, Wimmer AB, Licka M, Katus HA, Koenen M, Ulmer HE, Zehelein J. Thomas D, et al. Among authors: schweizer pa. J Mol Cell Cardiol. 2010 Jan;48(1):230-7. doi: 10.1016/j.yjmcc.2009.06.009. Epub 2009 Jun 21. J Mol Cell Cardiol. 2010. PMID: 19540844
147 results