Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis.
Rönnstrand L, Siegbahn A, Rorsman C, Johnell M, Hansen K, Heldin CH.
Rönnstrand L, et al. Among authors: siegbahn a.
J Biol Chem. 1999 Jul 30;274(31):22089-94. doi: 10.1074/jbc.274.31.22089.
J Biol Chem. 1999.
PMID: 10419537
Free article.
We have previously shown that porcine aortic endothelial cells expressing the Y934F platelet-derived growth factor (PDGF) beta-receptor mutant respond to PDGF-BB in a chemotaxis assay at about 100-fold lower concentration than do wild-type PDGF beta-receptor-expressing cel …
We have previously shown that porcine aortic endothelial cells expressing the Y934F platelet-derived growth factor (PDGF) beta-receptor muta …