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Blockade of individual Notch ligands and receptors controls graft-versus-host disease.
Tran IT, Sandy AR, Carulli AJ, Ebens C, Chung J, Shan GT, Radojcic V, Friedman A, Gridley T, Shelton A, Reddy P, Samuelson LC, Yan M, Siebel CW, Maillard I. Tran IT, et al. Among authors: siebel cw. J Clin Invest. 2013 Apr;123(4):1590-604. doi: 10.1172/JCI65477. J Clin Invest. 2013. PMID: 23454750 Free PMC article.
Therapeutic antibody targeting of individual Notch receptors.
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: siebel cw. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564
Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.
Wood S, Feng J, Chung J, Radojcic V, Sandy-Sloat AR, Friedman A, Shelton A, Yan M, Siebel CW, Bishop DK, Maillard I. Wood S, et al. Among authors: siebel cw. J Immunol. 2015 Mar 15;194(6):2899-908. doi: 10.4049/jimmunol.1402034. Epub 2015 Feb 16. J Immunol. 2015. PMID: 25687759 Free PMC article.
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Lafkas D, Shelton A, Chiu C, de Leon Boenig G, Chen Y, Stawicki SS, Siltanen C, Reichelt M, Zhou M, Wu X, Eastham-Anderson J, Moore H, Roose-Girma M, Chinn Y, Hang JQ, Warming S, Egen J, Lee WP, Austin C, Wu Y, Payandeh J, Lowe JB, Siebel CW. Lafkas D, et al. Among authors: siebel cw. Nature. 2015 Dec 3;528(7580):127-31. doi: 10.1038/nature15715. Epub 2015 Nov 18. Nature. 2015. PMID: 26580007
NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus.
Demitrack ES, Gifford GB, Keeley TM, Horita N, Todisco A, Turgeon DK, Siebel CW, Samuelson LC. Demitrack ES, et al. Among authors: siebel cw. Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G133-G144. doi: 10.1152/ajpgi.00325.2016. Epub 2016 Dec 8. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 27932500 Free PMC article.
71 results