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The development of highly potent inhibitors for porcupine.
Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. Wang X, et al. Among authors: lum l. J Med Chem. 2013 Mar 28;56(6):2700-4. doi: 10.1021/jm400159c. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23477365 Free PMC article.
Delivery of the Porcupine Inhibitor WNT974 in Mice.
Zhang LS, Lum L. Zhang LS, et al. Among authors: lum l. Methods Mol Biol. 2016;1481:111-7. doi: 10.1007/978-1-4939-6393-5_12. Methods Mol Biol. 2016. PMID: 27590157 Free PMC article.
Development of a triazole class of highly potent Porcn inhibitors.
You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L, Chen C. You L, et al. Among authors: lum l. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012. Epub 2016 Nov 11. Bioorg Med Chem Lett. 2016. PMID: 27876319 Free PMC article.
Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.
Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. Moon J, et al. Among authors: lum l. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31. Proc Natl Acad Sci U S A. 2017. PMID: 28143939 Free PMC article.
481 results