Shi H - Search Results

1

The development of highly potent inhibitors for porcupine.

Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. Wang X, et al. Among authors: shi h. J Med Chem. 2013 Mar 28;56(6):2700-4. doi: 10.1021/jm400159c. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23477365 Free PMC article.

2

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. Dodge ME, et al. Among authors: shi h. J Biol Chem. 2012 Jun 29;287(27):23246-54. doi: 10.1074/jbc.M112.372029. Epub 2012 May 15. J Biol Chem. 2012. PMID: 22593577 Free PMC article.

3

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. Wu J, et al. Among authors: shi h. Science. 2013 Feb 15;339(6121):826-30. doi: 10.1126/science.1229963. Epub 2012 Dec 20. Science. 2013. PMID: 23258412 Free PMC article.

4

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ. Zhang X, et al. Among authors: shi h. Mol Cell. 2013 Jul 25;51(2):226-35. doi: 10.1016/j.molcel.2013.05.022. Epub 2013 Jun 6. Mol Cell. 2013. PMID: 23747010 Free PMC article.

5

The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.

Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. Fan CW, et al. Among authors: shi h. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Chem Biol. 2014. PMID: 25484239 Free PMC article.

6

Identification and characterization of β-sitosterol target proteins.

Lomenick B, Shi H, Huang J, Chen C. Lomenick B, et al. Among authors: shi h. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4976-4979. doi: 10.1016/j.bmcl.2015.03.007. Epub 2015 Mar 11. Bioorg Med Chem Lett. 2015. PMID: 25804720 Free PMC article.

7

Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F.

Shi H, De S, Wang Q, Gao S, Wang X, Chen C. Shi H, et al. Tetrahedron Lett. 2015 Jun 3;56(23):3225-3227. doi: 10.1016/j.tetlet.2014.12.054. Tetrahedron Lett. 2015. PMID: 26097263 Free PMC article.

8

Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.

Shi H, Wu J, Chen ZJ, Chen C. Shi H, et al. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8947-52. doi: 10.1073/pnas.1507317112. Epub 2015 Jul 6. Proc Natl Acad Sci U S A. 2015. PMID: 26150511 Free PMC article.

9

cGAS is essential for the antitumor effect of immune checkpoint blockade.

Wang H, Hu S, Chen X, Shi H, Chen C, Sun L, Chen ZJ. Wang H, et al. Among authors: shi h. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1637-1642. doi: 10.1073/pnas.1621363114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137885 Free PMC article.

10

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation.

Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. Fan CW, et al. Among authors: shi h. Chem Biol. 2015 Apr 23;22(4):559. doi: 10.1016/j.chembiol.2015.04.001. Epub 2015 Apr 23. Chem Biol. 2015. PMID: 28934606 No abstract available.

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