Klempnauer KH - Search Results

1

Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships.

Schomburg C, Schuehly W, Da Costa FB, Klempnauer KH, Schmidt TJ. Schomburg C, et al. Among authors: klempnauer kh. Eur J Med Chem. 2013 May;63:313-20. doi: 10.1016/j.ejmech.2013.02.018. Epub 2013 Feb 26. Eur J Med Chem. 2013. PMID: 23501116

2

Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb.

Wilczek C, Chayka O, Plachetka A, Klempnauer KH. Wilczek C, et al. Among authors: klempnauer kh. J Biol Chem. 2009 Dec 18;284(51):35314-24. doi: 10.1074/jbc.M109.066175. J Biol Chem. 2009. PMID: 19841477 Free PMC article.

3

Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300.

Uttarkar S, Dukare S, Bopp B, Goblirsch M, Jose J, Klempnauer KH. Uttarkar S, et al. Among authors: klempnauer kh. Mol Cancer Ther. 2015 Jun;14(6):1276-85. doi: 10.1158/1535-7163.MCT-14-0662. Epub 2015 Mar 4. Mol Cancer Ther. 2015. PMID: 25740244

4

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.

Uttarkar S, Dassé E, Coulibaly A, Steinmann S, Jakobs A, Schomburg C, Trentmann A, Jose J, Schlenke P, Berdel WE, Schmidt TJ, Müller-Tidow C, Frampton J, Klempnauer KH. Uttarkar S, et al. Among authors: klempnauer kh. Blood. 2016 Mar 3;127(9):1173-82. doi: 10.1182/blood-2015-09-668632. Epub 2015 Dec 2. Blood. 2016. PMID: 26631113 Free article.

5

Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells.

Uttarkar S, Piontek T, Dukare S, Schomburg C, Schlenke P, Berdel WE, Müller-Tidow C, Schmidt TJ, Klempnauer KH. Uttarkar S, et al. Among authors: klempnauer kh. Mol Cancer Ther. 2016 Dec;15(12):2905-2915. doi: 10.1158/1535-7163.MCT-16-0185. Epub 2016 Oct 5. Mol Cancer Ther. 2016. PMID: 27707899

6

Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300.

Jakobs A, Steinmann S, Henrich SM, Schmidt TJ, Klempnauer KH. Jakobs A, et al. Among authors: klempnauer kh. J Biol Chem. 2016 Dec 9;291(50):26098-26108. doi: 10.1074/jbc.M116.748129. Epub 2016 Nov 1. J Biol Chem. 2016. PMID: 27803164 Free PMC article.

7

Targeting the transcription factor Myb by small-molecule inhibitors.

Uttarkar S, Frampton J, Klempnauer KH. Uttarkar S, et al. Among authors: klempnauer kh. Exp Hematol. 2017 Mar;47:31-35. doi: 10.1016/j.exphem.2016.12.003. Epub 2016 Dec 23. Exp Hematol. 2017. PMID: 28017646 Free article. Review.

8

Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ.

Falkenberg KD, Jakobs A, Matern JC, Dörner W, Uttarkar S, Trentmann A, Steinmann S, Coulibaly A, Schomburg C, Mootz HD, Schmidt TJ, Klempnauer KH. Falkenberg KD, et al. Among authors: klempnauer kh. Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1349-1358. doi: 10.1016/j.bbamcr.2017.05.003. Epub 2017 May 2. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28476645 Free article.

9

The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression.

Coulibaly A, Haas A, Steinmann S, Jakobs A, Schmidt TJ, Klempnauer KH. Coulibaly A, et al. Among authors: klempnauer kh. PLoS One. 2018 Feb 2;13(2):e0190934. doi: 10.1371/journal.pone.0190934. eCollection 2018. PLoS One. 2018. PMID: 29394256 Free PMC article.

10

A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity.

Yusenko M, Jakobs A, Klempnauer KH. Yusenko M, et al. Among authors: klempnauer kh. Sci Rep. 2018 Sep 3;8(1):13159. doi: 10.1038/s41598-018-31620-1. Sci Rep. 2018. PMID: 30177851 Free PMC article.

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