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Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.
Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. Wang P, et al. Among authors: zhou h, zhou y, zhou z. Mol Cell. 2014 May 8;54(3):378-91. doi: 10.1016/j.molcel.2014.03.007. Epub 2014 Apr 3. Mol Cell. 2014. PMID: 24703948 Free PMC article.
Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response.
Chen Z, Lin C, Pei H, Yuan X, Xu J, Zou M, Zhang X, Fossier A, Liu M, Goo S, Lei L, Yang J, Novick C, Xu J, Ying G, Zhou Z, Wu J, Tang C, Zhang W, Wang Z, Wang Z, Zhang H, Guo W, Hu Q, Ji H, Chen R. Chen Z, et al. Among authors: zhou z. Oncogenesis. 2023 Jun 22;12(1):33. doi: 10.1038/s41389-023-00480-4. Oncogenesis. 2023. PMID: 37349298 Free PMC article.
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