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The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.
Smith S, Hoyt J, Whitebread N, Manna J, Peluso M, Faia K, Campbell V, Tremblay M, Nair S, Grogan M, Castro A, Campbell M, Ferguson J, Arsenault B, Nevejans J, Carter B, Lee J, Dunbar J, McGovern K, Read M, Adams J, Constan A, Loewen G, Sydor J, Palombella V, Soglia J. Smith S, et al. Among authors: ferguson j. Xenobiotica. 2013 Oct;43(10):875-85. doi: 10.3109/00498254.2013.780671. Epub 2013 Mar 25. Xenobiotica. 2013. PMID: 23527529
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Tremblay MR, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M, White K, Conley J, Manna JD, Alvarez-Diez TM, Hoyt J, Woodward CN, Sydor JR, Pink M, MacDougall J, Campbell MJ, Cushing J, Ferguson J, Curtis MS, McGovern K, Read MA, Palombella VJ, Adams J, Castro AC. Tremblay MR, et al. Among authors: ferguson j. J Med Chem. 2009 Jul 23;52(14):4400-18. doi: 10.1021/jm900305z. J Med Chem. 2009. PMID: 19522463
Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.
McCann CK, Growdon WB, Kulkarni-Datar K, Curley MD, Friel AM, Proctor JL, Sheikh H, Deyneko I, Ferguson JA, Vathipadiekal V, Birrer MJ, Borger DR, Mohapatra G, Zukerberg LR, Foster R, Macdougall JR, Rueda BR. McCann CK, et al. Among authors: ferguson ja. PLoS One. 2011;6(11):e28077. doi: 10.1371/journal.pone.0028077. Epub 2011 Nov 29. PLoS One. 2011. PMID: 22140510 Free PMC article.
Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression.
Vionnet J, Torres-Yaguana J, Miquel R, Abraldes JG, Wall J, Kodela E, Lozano JJ, Ruiz P, Navasa M, Marshall A, Nevens F, Gelson W, Leithead J, Masson S, Jaeckel E, Taubert R, Tachtatzis P, Eurich D, Simpson KJ, Bonaccorsi-Riani E, Ferguson J, Quaglia A, Demetris AJ, Lesniak AJ, Elstad M, Delord M, Douiri A, Rebollo-Mesa I, Martinez-Llordella M, Silva JAF, Markmann JF, Sánchez-Fueyo A. Vionnet J, et al. Among authors: ferguson j. Am J Transplant. 2024 Dec 18:S1600-6135(24)00749-4. doi: 10.1016/j.ajt.2024.12.002. Online ahead of print. Am J Transplant. 2024. PMID: 39706366 Free article.
Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures.
Quraishi MN, Cheesbrough J, Rimmer P, Mullish BH, Sharma N, Efstathiou E, Acharjee A, Gkoutus G, Patel A, Marchesi JR, Camuzeaux S, Chappell K, Valdivia-Garcia MA, Ferguson J, Brookes M, Walmsley M, Rossiter A, van Schaik W, McInnes RS, Cooney R, Trauner M, Beggs A, Iqbal T, Trivedi PJ. Quraishi MN, et al. Among authors: ferguson j. J Crohns Colitis. 2024 Dec 14:jjae189. doi: 10.1093/ecco-jcc/jjae189. Online ahead of print. J Crohns Colitis. 2024. PMID: 39673746
Circulating Tumor DNA as a Prognostic Biomarker for Recurrence in Patients With Locoregional Esophagogastric Cancers With a Pathologic Complete Response.
Lander EM, Aushev VN, Huffman BM, Hanna D, Dutta P, Ferguson J, Sharma S, Jurdi A, Liu MC, Eng C, Klempner SJ, Gibson MK. Lander EM, et al. Among authors: ferguson j. JCO Precis Oncol. 2024 Dec;8:e2400288. doi: 10.1200/PO.24.00288. Epub 2024 Dec 6. JCO Precis Oncol. 2024. PMID: 39642325 Free PMC article.
3,426 results