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Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH. Hopkins SC, et al. Among authors: koch p. J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30. J Med Chem. 2013. PMID: 23631755
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Shao L, Wang F, Malcolm SC, Ma J, Hewitt MC, Campbell UC, Bush LR, Spicer NA, Engel SR, Saraswat LD, Hardy LW, Koch P, Schreiber R, Spear KL, Varney MA. Shao L, et al. Among authors: koch p. Bioorg Med Chem. 2011 Jan 1;19(1):663-76. doi: 10.1016/j.bmc.2010.10.034. Epub 2010 Oct 21. Bioorg Med Chem. 2011. PMID: 21093273
Derivatives of tramadol for increased duration of effect.
Shao L, Abolin C, Hewitt MC, Koch P, Varney M. Shao L, et al. Among authors: koch p. Bioorg Med Chem Lett. 2006 Feb;16(3):691-4. doi: 10.1016/j.bmcl.2005.10.024. Epub 2005 Oct 27. Bioorg Med Chem Lett. 2006. PMID: 16257206
Evolution and synthesis of novel orally bioavailable inhibitors of PDE10A.
Burdi DF, Campbell JE, Wang J, Zhao S, Zhong H, Wei J, Campbell U, Shao L, Herman L, Koch P, Jones PG, Hewitt MC. Burdi DF, et al. Among authors: koch p. Bioorg Med Chem Lett. 2015 May 1;25(9):1864-8. doi: 10.1016/j.bmcl.2015.03.050. Epub 2015 Mar 26. Bioorg Med Chem Lett. 2015. PMID: 25863433
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.
Shao L, Hewitt M, Jerussi TP, Wu F, Malcolm S, Grover P, Fang K, Koch P, Senanayake C, Bhongle N, Ribe S, Bakale R, Currie M. Shao L, et al. Among authors: koch p. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1674-80. doi: 10.1016/j.bmcl.2008.01.051. Epub 2008 Jan 18. Bioorg Med Chem Lett. 2008. PMID: 18242987
Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings.
Henick BS, Koch PD, Gainor JF, Awad MM, Chiuzan C, Izard S, Georgis Y, Mallick S, Garofano RF, Wong CV, Saqi A, Grindheim J, Schulze K, Sonett JR, Rizvi NA, Izar B, Taylor AM, Shu CA. Henick BS, et al. Among authors: koch pd. J Immunother Cancer. 2024 Dec 25;12(12):e009301. doi: 10.1136/jitc-2024-009301. J Immunother Cancer. 2024. PMID: 39721753 Free article. Clinical Trial.
1,158 results