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Suppression of autophagy in osteocytes mimics skeletal aging.
Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Onal M, et al. Among authors: manolagas sc. J Biol Chem. 2013 Jun 14;288(24):17432-40. doi: 10.1074/jbc.M112.444190. Epub 2013 May 3. J Biol Chem. 2013. PMID: 23645674 Free PMC article.
Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Bellido T, et al. Among authors: manolagas sc. J Biol Chem. 2003 Dec 12;278(50):50259-72. doi: 10.1074/jbc.M307444200. Epub 2003 Oct 1. J Biol Chem. 2003. PMID: 14523023 Free article.
220 results