Kozielski F - Search Results

1

"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.

Kaan HY, Major J, Tkocz K, Kozielski F, Rosenfeld SS. Kaan HY, et al. Among authors: kozielski f. J Biol Chem. 2013 Jun 21;288(25):18588-98. doi: 10.1074/jbc.M113.462648. Epub 2013 May 8. J Biol Chem. 2013. PMID: 23658017 Free PMC article.

2

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

Skoufias DA, DeBonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D, Kozielski F. Skoufias DA, et al. Among authors: kozielski f. J Biol Chem. 2006 Jun 30;281(26):17559-69. doi: 10.1074/jbc.M511735200. Epub 2006 Feb 28. J Biol Chem. 2006. PMID: 16507573 Free article.

3

Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.

Garcia-Saez I, DeBonis S, Lopez R, Trucco F, Rousseau B, Thuéry P, Kozielski F. Garcia-Saez I, et al. Among authors: kozielski f. J Biol Chem. 2007 Mar 30;282(13):9740-9747. doi: 10.1074/jbc.M608883200. Epub 2007 Jan 23. J Biol Chem. 2007. PMID: 17251189 Free article.

4

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

Kozielski F, Skoufias DA, Indorato RL, Saoudi Y, Jungblut PR, Hustoft HK, Strozynski M, Thiede B. Kozielski F, et al. Proteomics. 2008 Jan;8(2):289-300. doi: 10.1002/pmic.200700534. Proteomics. 2008. PMID: 18186019

5

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F. Debonis S, et al. Among authors: kozielski f. J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266314

6

An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.

Kaan HY, Ulaganathan V, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Biochem J. 2009 Dec 14;425(1):55-60. doi: 10.1042/BJ20091207. Biochem J. 2009. PMID: 19793049

7

Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.

Kaan HY, Ulaganathan V, Rath O, Prokopcová H, Dallinger D, Kappe CO, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2010 Aug 12;53(15):5676-83. doi: 10.1021/jm100421n. J Med Chem. 2010. PMID: 20597485

8

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

Prokopcová H, Dallinger D, Uray G, Kaan HY, Ulaganathan V, Kozielski F, Laggner C, Kappe CO. Prokopcová H, et al. Among authors: kozielski f. ChemMedChem. 2010 Oct 4;5(10):1760-9. doi: 10.1002/cmdc.201000252. ChemMedChem. 2010. PMID: 20737530

9

Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

Kaan HY, Weiss J, Menger D, Ulaganathan V, Tkocz K, Laggner C, Popowycz F, Joseph B, Kozielski F. Kaan HY, et al. Among authors: kozielski f. J Med Chem. 2011 Mar 24;54(6):1576-86. doi: 10.1021/jm100991m. Epub 2011 Feb 23. J Med Chem. 2011. PMID: 21344920

10

The structure of the kinesin-1 motor-tail complex reveals the mechanism of autoinhibition.

Kaan HY, Hackney DD, Kozielski F. Kaan HY, et al. Among authors: kozielski f. Science. 2011 Aug 12;333(6044):883-5. doi: 10.1126/science.1204824. Science. 2011. PMID: 21836017 Free PMC article.

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