Clem AL - Search Results

1

Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer.

Clem BF, O'Neal J, Tapolsky G, Clem AL, Imbert-Fernandez Y, Kerr DA 2nd, Klarer AC, Redman R, Miller DM, Trent JO, Telang S, Chesney J. Clem BF, et al. Among authors: clem al. Mol Cancer Ther. 2013 Aug;12(8):1461-70. doi: 10.1158/1535-7163.MCT-13-0097. Epub 2013 May 14. Mol Cancer Ther. 2013. PMID: 23674815 Free PMC article.

2

Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases.

Yalcin A, Clem BF, Simmons A, Lane A, Nelson K, Clem AL, Brock E, Siow D, Wattenberg B, Telang S, Chesney J. Yalcin A, et al. Among authors: clem al. J Biol Chem. 2009 Sep 4;284(36):24223-32. doi: 10.1074/jbc.M109.016816. Epub 2009 May 27. J Biol Chem. 2009. PMID: 19473963 Free PMC article.

3

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation.

Telang S, Clem BF, Klarer AC, Clem AL, Trent JO, Bucala R, Chesney J. Telang S, et al. Among authors: clem al. J Transl Med. 2012 May 16;10:95. doi: 10.1186/1479-5876-10-95. J Transl Med. 2012. PMID: 22591674 Free PMC article.

4

Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3).

Imbert-Fernandez Y, Clem BF, O'Neal J, Kerr DA, Spaulding R, Lanceta L, Clem AL, Telang S, Chesney J. Imbert-Fernandez Y, et al. Among authors: clem al. J Biol Chem. 2014 Mar 28;289(13):9440-8. doi: 10.1074/jbc.M113.529990. Epub 2014 Feb 10. J Biol Chem. 2014. PMID: 24515104 Free PMC article.

5

A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling.

Clem BF, Clem AL, Yalcin A, Goswami U, Arumugam S, Telang S, Trent JO, Chesney J. Clem BF, et al. Among authors: clem al. Oncogene. 2011 Jul 28;30(30):3370-80. doi: 10.1038/onc.2011.51. Epub 2011 Mar 21. Oncogene. 2011. PMID: 21423211 Free PMC article.

6

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27.

Yalcin A, Clem BF, Imbert-Fernandez Y, Ozcan SC, Peker S, O'Neal J, Klarer AC, Clem AL, Telang S, Chesney J. Yalcin A, et al. Among authors: clem al. Cell Death Dis. 2014 Jul 17;5(7):e1337. doi: 10.1038/cddis.2014.292. Cell Death Dis. 2014. PMID: 25032860 Free PMC article.

7

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

Clem B, Telang S, Clem A, Yalcin A, Meier J, Simmons A, Rasku MA, Arumugam S, Dean WL, Eaton J, Lane A, Trent JO, Chesney J. Clem B, et al. Mol Cancer Ther. 2008 Jan;7(1):110-20. doi: 10.1158/1535-7163.MCT-07-0482. Mol Cancer Ther. 2008. PMID: 18202014

8

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism.

Klarer AC, O'Neal J, Imbert-Fernandez Y, Clem A, Ellis SR, Clark J, Clem B, Chesney J, Telang S. Klarer AC, et al. Cancer Metab. 2014 Jan 23;2(1):2. doi: 10.1186/2049-3002-2-2. Cancer Metab. 2014. PMID: 24451478 Free PMC article.

9

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer.

O'Neal J, Clem A, Reynolds L, Dougherty S, Imbert-Fernandez Y, Telang S, Chesney J, Clem BF. O'Neal J, et al. Breast Cancer Res Treat. 2016 Nov;160(1):29-40. doi: 10.1007/s10549-016-3968-8. Epub 2016 Sep 9. Breast Cancer Res Treat. 2016. PMID: 27613609

10

Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model.

Telang S, Clem AL, Eaton JW, Chesney J. Telang S, et al. Among authors: clem al. Neoplasia. 2007 Jan;9(1):47-56. doi: 10.1593/neo.06664. Neoplasia. 2007. PMID: 17325743 Free PMC article.

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