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Molecular mechanism of biased signaling at the kappa opioid receptor.
El Daibani A, Paggi JM, Kim K, Laloudakis YD, Popov P, Bernhard SM, Krumm BE, Olsen RHJ, Diberto J, Carroll FI, Katritch V, Wünsch B, Dror RO, Che T. El Daibani A, et al. Among authors: dror ro. Nat Commun. 2023 Mar 11;14(1):1338. doi: 10.1038/s41467-023-37041-7. Nat Commun. 2023. PMID: 36906681 Free PMC article.
A positively tuned voltage indicator for extended electrical recordings in the brain.
Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, Fan JL, Hwang FJ, van Keulen SC, Suomivuori CM, Pang MM, Su S, Lee S, Hao YA, Zhang G, Jiang D, Pradhan L, Roth RH, Liu Y, Dorian CC, Reese AL, Negrean A, Losonczy A, Makinson CD, Wang S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ. Evans SW, et al. Among authors: dror ro. Nat Methods. 2023 Jul;20(7):1104-1113. doi: 10.1038/s41592-023-01913-z. Epub 2023 Jul 6. Nat Methods. 2023. PMID: 37429962 Free PMC article.
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR.
Ople RS, Ramos-Gonzalez N, Li Q, Sobecks BL, Aydin D, Powers AS, Faouzi A, Polacco BJ, Bernhard SM, Appourchaux K, Sribhashyam S, Eans SO, Tsai BA, Dror RO, Varga BR, Wang H, Hüttenhain R, McLaughlin JP, Majumdar S. Ople RS, et al. Among authors: dror ro. ACS Cent Sci. 2024 Jul 17;10(8):1490-1503. doi: 10.1021/acscentsci.4c00525. eCollection 2024 Aug 28. ACS Cent Sci. 2024. PMID: 39220695 Free PMC article.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: dror ro. Nat Chem Biol. 2023 Apr;19(4):529. doi: 10.1038/s41589-023-01297-3. Nat Chem Biol. 2023. PMID: 36879062 Free PMC article. No abstract available.
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM. Burger WAC, et al. Among authors: dror ro. Nat Commun. 2023 Sep 6;14(1):5440. doi: 10.1038/s41467-023-41199-5. Nat Commun. 2023. PMID: 37673901 Free PMC article.
122 results