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Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Roversi P, Marti L, Caputo AT, Alonzi DS, Hill JC, Dent KC, Kumar A, Levasseur MD, Lia A, Waksman T, Basu S, Soto Albrecht Y, Qian K, McIvor JP, Lipp CB, Siliqi D, Vasiljević S, Mohammed S, Lukacik P, Walsh MA, Santino A, Zitzmann N. Roversi P, et al. Among authors: alonzi ds. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8544-8549. doi: 10.1073/pnas.1703682114. Epub 2017 Jul 24. Proc Natl Acad Sci U S A. 2017. PMID: 28739903 Free PMC article.
Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase.
Modenutti CP, Blanco Capurro JI, Ibba R, Alonzi DS, Song MN, Vasiljević S, Kumar A, Chandran AV, Tax G, Marti L, Hill JC, Lia A, Hensen M, Waksman T, Rushton J, Rubichi S, Santino A, Martí MA, Zitzmann N, Roversi P. Modenutti CP, et al. Among authors: alonzi ds. Structure. 2021 Apr 1;29(4):357-370.e9. doi: 10.1016/j.str.2020.11.017. Epub 2020 Dec 21. Structure. 2021. PMID: 33352114 Free PMC article.
Urinary glycan markers for disease.
Alonzi DS, Su YH, Butters TD. Alonzi DS, et al. Biochem Soc Trans. 2011 Jan;39(1):393-8. doi: 10.1042/BST0390393. Biochem Soc Trans. 2011. PMID: 21265811 Review.
Iminosugar antivirals: the therapeutic sweet spot.
Alonzi DS, Scott KA, Dwek RA, Zitzmann N. Alonzi DS, et al. Biochem Soc Trans. 2017 Apr 15;45(2):571-582. doi: 10.1042/BST20160182. Biochem Soc Trans. 2017. PMID: 28408497 Free PMC article. Review.
47 results