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Page 1
Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276.
Schmidt J, Braggio E, Kortuem KM, Egan JB, Zhu YX, Xin CS, Tiedemann RE, Palmer SE, Garbitt VM, McCauley D, Kauffman M, Shacham S, Chesi M, Bergsagel PL, Stewart AK. Schmidt J, et al. Among authors: kortuem km. Leukemia. 2013 Dec;27(12):2357-65. doi: 10.1038/leu.2013.172. Epub 2013 Jun 11. Leukemia. 2013. PMID: 23752175 Free PMC article.
The clinical significance of cereblon expression in multiple myeloma.
Schuster SR, Kortuem KM, Zhu YX, Braggio E, Shi CX, Bruins LA, Schmidt JE, Ahmann G, Kumar S, Rajkumar SV, Mikhael J, Laplant B, Champion MD, Laumann K, Barlogie B, Fonseca R, Bergsagel PL, Lacy M, Stewart AK. Schuster SR, et al. Among authors: kortuem km. Leuk Res. 2014 Jan;38(1):23-8. doi: 10.1016/j.leukres.2013.08.015. Epub 2013 Sep 5. Leuk Res. 2014. PMID: 24129344 Free PMC article.
Carfilzomib.
Kortuem KM, Stewart AK. Kortuem KM, et al. Blood. 2013 Feb 7;121(6):893-7. doi: 10.1182/blood-2012-10-459883. Blood. 2013. PMID: 23393020 Free article. Review.
Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma.
Zhu YX, Braggio E, Shi CX, Kortuem KM, Bruins LA, Schmidt JE, Chang XB, Langlais P, Luo M, Jedlowski P, LaPlant B, Laumann K, Fonseca R, Bergsagel PL, Mikhael J, Lacy M, Champion MD, Stewart AK. Zhu YX, et al. Among authors: kortuem km. Blood. 2014 Jul 24;124(4):536-45. doi: 10.1182/blood-2014-02-557819. Epub 2014 Jun 9. Blood. 2014. PMID: 24914135 Free PMC article.
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements.
Egan JB, Barrett MT, Champion MD, Middha S, Lenkiewicz E, Evers L, Francis P, Schmidt J, Shi CX, Van Wier S, Badar S, Ahmann G, Kortuem KM, Boczek NJ, Fonseca R, Craig DW, Carpten JD, Borad MJ, Stewart AK. Egan JB, et al. Among authors: kortuem km. PLoS One. 2014 Feb 5;9(2):e87113. doi: 10.1371/journal.pone.0087113. eCollection 2014. PLoS One. 2014. PMID: 24505276 Free PMC article. Clinical Trial.
Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease.
Egan JB, Kortuem KM, Kurdoglu A, Izatt T, Aldrich J, Reiman R, Phillips L, Baker A, Shi CX, Schmidt J, Liang WS, Craig DW, Carpten JD, Stewart AK. Egan JB, et al. Among authors: kortuem km. Br J Haematol. 2013 Jun;161(5):748-751. doi: 10.1111/bjh.12291. Epub 2013 Mar 11. Br J Haematol. 2013. PMID: 23480694 Free PMC article. No abstract available.
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