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Page 1
Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.
Unruh D, Turner K, Srinivasan R, Kocatürk B, Qi X, Chu Z, Aronow BJ, Plas DR, Gallo CA, Kalthoff H, Kirchhofer D, Ruf W, Ahmad SA, Lucas FV, Versteeg HH, Bogdanov VY. Unruh D, et al. Among authors: kirchhofer d. Int J Cancer. 2014 Jan 1;134(1):9-20. doi: 10.1002/ijc.28327. Epub 2013 Jul 27. Int J Cancer. 2014. PMID: 23754313 Free PMC article.
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.
Wang JG, Geddings JE, Aleman MM, Cardenas JC, Chantrathammachart P, Williams JC, Kirchhofer D, Bogdanov VY, Bach RR, Rak J, Church FC, Wolberg AS, Pawlinski R, Key NS, Yeh JJ, Mackman N. Wang JG, et al. Among authors: kirchhofer d. Blood. 2012 Jun 7;119(23):5543-52. doi: 10.1182/blood-2012-01-402156. Epub 2012 Apr 30. Blood. 2012. PMID: 22547577 Free PMC article.
Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils.
Heestermans M, Salloum-Asfar S, Streef T, Laghmani EH, Salvatori D, Luken BM, Zeerleder SS, Spronk HMH, Korporaal SJ, Kirchhofer D, Wagenaar GTM, Versteeg HH, Reitsma PH, Renné T, van Vlijmen BJM. Heestermans M, et al. Among authors: kirchhofer d. Blood. 2019 May 9;133(19):2090-2099. doi: 10.1182/blood-2018-06-853762. Epub 2019 Mar 21. Blood. 2019. PMID: 30898865 Free article.
Excess of heme induces tissue factor-dependent activation of coagulation in mice.
Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R. Sparkenbaugh EM, et al. Among authors: kirchhofer d. Haematologica. 2015 Mar;100(3):308-14. doi: 10.3324/haematol.2014.114728. Epub 2015 Jan 16. Haematologica. 2015. PMID: 25596265 Free PMC article.
Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.
Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. Owens AP 3rd, et al. Among authors: kirchhofer d. J Clin Invest. 2012 Feb;122(2):558-68. doi: 10.1172/JCI58969. Epub 2012 Jan 3. J Clin Invest. 2012. PMID: 22214850 Free PMC article.
PAR-1 contributes to the innate immune response during viral infection.
Antoniak S, Owens AP 3rd, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall BC, Pawlinski R, Beck MA, Rauch U, Mackman N. Antoniak S, et al. Among authors: kirchhofer d. J Clin Invest. 2013 Mar;123(3):1310-22. doi: 10.1172/JCI66125. Epub 2013 Feb 8. J Clin Invest. 2013. PMID: 23391721 Free PMC article.
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