Getlik M - Search Results

1

Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

Richters A, Ketzer J, Getlik M, Grütter C, Schneider R, Heuckmann JM, Heynck S, Sos ML, Gupta A, Unger A, Schultz-Fademrecht C, Thomas RK, Bauer S, Rauh D. Richters A, et al. Among authors: getlik m. J Med Chem. 2013 Jul 25;56(14):5757-72. doi: 10.1021/jm4004076. Epub 2013 Jul 10. J Med Chem. 2013. PMID: 23773153

2

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.

Getlik M, Grütter C, Simard JR, Klüter S, Rabiller M, Rode HB, Robubi A, Rauh D. Getlik M, et al. J Med Chem. 2009 Jul 9;52(13):3915-26. doi: 10.1021/jm9002928. J Med Chem. 2009. PMID: 19462975

3

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: getlik m. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

4

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Getlik M, Grütter C, Simard JR, Nguyen HD, Robubi A, Aust B, van Otterlo WA, Rauh D. Getlik M, et al. Eur J Med Chem. 2012 Feb;48:1-15. doi: 10.1016/j.ejmech.2011.11.019. Epub 2011 Nov 18. Eur J Med Chem. 2012. PMID: 22154891

5

Direct binding assay for the detection of type IV allosteric inhibitors of Abl.

Schneider R, Becker C, Simard JR, Getlik M, Bohlke N, Janning P, Rauh D. Schneider R, et al. Among authors: getlik m. J Am Chem Soc. 2012 Jun 6;134(22):9138-41. doi: 10.1021/ja303858w. Epub 2012 May 25. J Am Chem Soc. 2012. PMID: 22612329

6

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Engel J, Richters A, Getlik M, Tomassi S, Keul M, Termathe M, Lategahn J, Becker C, Mayer-Wrangowski S, Grütter C, Uhlenbrock N, Krüll J, Schaumann N, Eppmann S, Kibies P, Hoffgaard F, Heil J, Menninger S, Ortiz-Cuaran S, Heuckmann JM, Tinnefeld V, Zahedi RP, Sos ML, Schultz-Fademrecht C, Thomas RK, Kast SM, Rauh D. Engel J, et al. Among authors: getlik m. J Med Chem. 2015 Sep 10;58(17):6844-63. doi: 10.1021/acs.jmedchem.5b01082. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26275028

7

A new screening assay for allosteric inhibitors of cSrc.

Simard JR, Klüter S, Grütter C, Getlik M, Rabiller M, Rode HB, Rauh D. Simard JR, et al. Among authors: getlik m. Nat Chem Biol. 2009 Jun;5(6):394-6. doi: 10.1038/nchembio.162. Epub 2009 Apr 26. Nat Chem Biol. 2009. PMID: 19396179

8

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D. Simard JR, et al. Among authors: getlik m. J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p. J Am Chem Soc. 2009. PMID: 19572644

9

Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.

Simard JR, Getlik M, Grütter C, Schneider R, Wulfert S, Rauh D. Simard JR, et al. Among authors: getlik m. J Am Chem Soc. 2010 Mar 31;132(12):4152-60. doi: 10.1021/ja908083e. J Am Chem Soc. 2010. PMID: 20201574

10

Proteus in the world of proteins: conformational changes in protein kinases.

Rabiller M, Getlik M, Klüter S, Richters A, Tückmantel S, Simard JR, Rauh D. Rabiller M, et al. Among authors: getlik m. Arch Pharm (Weinheim). 2010 Apr;343(4):193-206. doi: 10.1002/ardp.201000028. Arch Pharm (Weinheim). 2010. PMID: 20336692 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

23 results

Search Page

Filters