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The majority of metachronous CIN1 and CIN3 lesions are caused by different human papillomavirus genotypes, indicating that the presence of CIN1 seems not to determine the risk for subsequent detection of CIN3.
Litjens RJ, Van de Vijver KK, Hopman AH, Ummelen MI, Speel EJ, Sastrowijoto SH, Van Gorp T, Slangen BF, Kruitwagen RF, Krüse AJ. Litjens RJ, et al. Hum Pathol. 2014 Feb;45(2):221-6. doi: 10.1016/j.humpath.2013.10.014. Epub 2013 Oct 30. Hum Pathol. 2014. PMID: 24439220
Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies.
Theelen W, Litjens RJ, Vinokurova S, Haesevoets A, Reijans M, Simons G, Smedts F, Herrington CS, Ramaekers FC, von Knebel Doeberitz M, Speel EJ, Hopman AH. Theelen W, et al. Among authors: litjens rj. Hum Pathol. 2013 Nov;44(11):2410-8. doi: 10.1016/j.humpath.2013.04.026. Epub 2013 Aug 19. Hum Pathol. 2013. PMID: 23968641 Free article.
SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN.
Moshi JM, Ummelen M, Broers JLV, Smedts F, Van de Vijver KK, Cleutjens JPM, Litjens RJNTM, Ramaekers FCS, Hopman AHN. Moshi JM, et al. Among authors: litjens rjntm. Histochem Cell Biol. 2022 Dec;158(6):545-559. doi: 10.1007/s00418-022-02145-6. Epub 2022 Aug 9. Histochem Cell Biol. 2022. PMID: 35945296 Free PMC article.