Kelley RF - Search Results

1

A strategy for risk mitigation of antibodies with fast clearance.

Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. Hötzel I, et al. Among authors: kelley rf. MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189. MAbs. 2012. PMID: 23778268 Free PMC article.

2

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments.

Kelley RF, O'Connell MP, Carter P, Presta L, Eigenbrot C, Covarrubias M, Snedecor B, Bourell JH, Vetterlein D. Kelley RF, et al. Biochemistry. 1992 Jun 23;31(24):5434-41. doi: 10.1021/bi00139a003. Biochemistry. 1992. PMID: 1351741

3

High level Escherichia coli expression and production of a bivalent humanized antibody fragment.

Carter P, Kelley RF, Rodrigues ML, Snedecor B, Covarrubias M, Velligan MD, Wong WL, Rowland AM, Kotts CE, Carver ME, et al. Carter P, et al. Among authors: kelley rf. Biotechnology (N Y). 1992 Feb;10(2):163-7. doi: 10.1038/nbt0292-163. Biotechnology (N Y). 1992. PMID: 1368228

4

Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function.

Kelley RF, Meng YG. Kelley RF, et al. Methods Mol Biol. 2012;901:277-93. doi: 10.1007/978-1-61779-931-0_18. Methods Mol Biol. 2012. PMID: 22723108

5

Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG.

Wang X, Quarmby V, Ng C, Chuntharapai A, Shek T, Eigenbrot C, Kelley RF, Shia S, McCutcheon K, Lowe J, Leddy C, Coachman K, Cain G, Chu F, Hotzel I, Maia M, Wakshull E, Yang J. Wang X, et al. Among authors: kelley rf. MAbs. 2013 Jul-Aug;5(4):540-54. doi: 10.4161/mabs.24822. Epub 2013 Apr 29. MAbs. 2013. PMID: 23774668 Free PMC article.

6

Development and preclinical characterization of a humanized antibody targeting CXCL12.

Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. Zhong C, et al. Among authors: kelley rf. Clin Cancer Res. 2013 Aug 15;19(16):4433-45. doi: 10.1158/1078-0432.CCR-13-0943. Epub 2013 Jun 28. Clin Cancer Res. 2013. PMID: 23812669

7

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity.

Shatz W, Chung S, Li B, Marshall B, Tejada M, Phung W, Sandoval W, Kelley RF, Scheer JM. Shatz W, et al. Among authors: kelley rf. MAbs. 2013 Nov-Dec;5(6):872-81. doi: 10.4161/mabs.26307. Epub 2013 Aug 29. MAbs. 2013. PMID: 23995614 Free PMC article.

8

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation.

Li B, Fouts AE, Stengel K, Luan P, Dillon M, Liang WC, Feierbach B, Kelley RF, Hötzel I. Li B, et al. Among authors: kelley rf. MAbs. 2014 Mar-Apr;6(2):437-45. doi: 10.4161/mabs.27875. Epub 2014 Jan 16. MAbs. 2014. PMID: 24492299 Free PMC article.

9

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

Leabman MK, Meng YG, Kelley RF, DeForge LE, Cowan KJ, Iyer S. Leabman MK, et al. Among authors: kelley rf. MAbs. 2013 Nov-Dec;5(6):896-903. doi: 10.4161/mabs.26436. MAbs. 2013. PMID: 24492343 Free PMC article.

10

In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability.

Sharma VK, Patapoff TW, Kabakoff B, Pai S, Hilario E, Zhang B, Li C, Borisov O, Kelley RF, Chorny I, Zhou JZ, Dill KA, Swartz TE. Sharma VK, et al. Among authors: kelley rf. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18601-6. doi: 10.1073/pnas.1421779112. Epub 2014 Dec 15. Proc Natl Acad Sci U S A. 2014. PMID: 25512516 Free PMC article.

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