Piazza GA - Search Results

1

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.

Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA. Li N, et al. Among authors: piazza ga. Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26. Mol Cancer Ther. 2013. PMID: 23804703 Free PMC article.

2

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

Thompson WJ, Piazza GA, Li H, Liu L, Fetter J, Zhu B, Sperl G, Ahnen D, Pamukcu R. Thompson WJ, et al. Among authors: piazza ga. Cancer Res. 2000 Jul 1;60(13):3338-42. Cancer Res. 2000. PMID: 10910034

3

Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.

Whitehead CM, Earle KA, Fetter J, Xu S, Hartman T, Chan DC, Zhao TL, Piazza G, Klein-Szanto AJ, Pamukcu R, Alila H, Bunn PA Jr, Thompson WJ. Whitehead CM, et al. Mol Cancer Ther. 2003 May;2(5):479-88. Mol Cancer Ther. 2003. PMID: 12748310

4

Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells.

Rice PL, Kelloff J, Sullivan H, Driggers LJ, Beard KS, Kuwada S, Piazza G, Ahnen DJ. Rice PL, et al. Mol Cancer Ther. 2003 Sep;2(9):885-92. Mol Cancer Ther. 2003. PMID: 14555707

5

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.

Lu W, Tinsley HN, Keeton A, Qu Z, Piazza GA, Li Y. Lu W, et al. Among authors: piazza ga. Eur J Pharmacol. 2009 Jan 5;602(1):8-14. doi: 10.1016/j.ejphar.2008.10.053. Epub 2008 Nov 9. Eur J Pharmacol. 2009. PMID: 19026633 Free PMC article.

6

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, Reynolds RC. Piazza GA, et al. Cancer Prev Res (Phila). 2009 Jun;2(6):572-80. doi: 10.1158/1940-6207.CAPR-09-0001. Epub 2009 May 26. Cancer Prev Res (Phila). 2009. PMID: 19470791 Free PMC article.

7

Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors.

Abadi AH, Ibrahim TM, Abouzid KM, Lehmann J, Tinsley HN, Gary BD, Piazza GA. Abadi AH, et al. Among authors: piazza ga. Bioorg Med Chem. 2009 Aug 15;17(16):5974-82. doi: 10.1016/j.bmc.2009.06.063. Epub 2009 Jul 3. Bioorg Med Chem. 2009. PMID: 19628397 Free PMC article.

8

Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.

Abadi AH, Abouel-Ella DA, Ahmed NS, Gary BD, Thaiparambil JT, Tinsley HN, Keeton AB, Piazza GA. Abadi AH, et al. Among authors: piazza ga. Arzneimittelforschung. 2009;59(8):415-21. doi: 10.1055/s-0031-1296417. Arzneimittelforschung. 2009. PMID: 19813465 Free PMC article.

9

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.

Abadi AH, Abouel-Ella DA, Lehmann J, Tinsley HN, Gary BD, Piazza GA, Abdel-Fattah MA. Abadi AH, et al. Among authors: piazza ga. Eur J Med Chem. 2010 Jan;45(1):90-7. doi: 10.1016/j.ejmech.2009.09.029. Epub 2009 Sep 20. Eur J Med Chem. 2010. PMID: 19836860 Free PMC article.

10

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.

Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA. Tinsley HN, et al. Among authors: piazza ga. Mol Cancer Ther. 2009 Dec;8(12):3331-40. doi: 10.1158/1535-7163.MCT-09-0758. Mol Cancer Ther. 2009. PMID: 19996273 Free PMC article.

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