Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.
Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, Woods I, Prehn JH, Henshall DC.
Engel T, et al.
FASEB J. 2010 Mar;24(3):853-61. doi: 10.1096/fj.09-145870. Epub 2009 Nov 4.
FASEB J. 2010.
PMID: 19890018
Free PMC article.
These are the first data showing genetic deletion of a proapoptotic protein acting acutely to influence neuronal death subsequently alters the phenotype of epilepsy in the long-term, supporting the concept that apoptotic pathway activation is a trigger of epileptogenesis.-Enge …
These are the first data showing genetic deletion of a proapoptotic protein acting acutely to influence neuronal death subsequently alters t …