Proia DA - Search Results

1

Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3.

Nagaraju GP, Park W, Wen J, Mahaseth H, Landry J, Farris AB, Willingham F, Sullivan PS, Proia DA, El-Hariry I, Taliaferro-Smith L, Diaz R, El-Rayes BF. Nagaraju GP, et al. Among authors: proia da. Angiogenesis. 2013 Oct;16(4):903-17. doi: 10.1007/s10456-013-9364-7. Epub 2013 Jul 10. Angiogenesis. 2013. PMID: 23838996

2

Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.

Proia DA, Zhang C, Sequeira M, Jimenez JP, He S, Spector N, Shapiro GI, Tolaney S, Nagai M, Acquaviva J, Smith DL, Sang J, Bates RC, El-Hariry I. Proia DA, et al. Clin Cancer Res. 2014 Jan 15;20(2):413-24. doi: 10.1158/1078-0432.CCR-13-2166. Epub 2013 Oct 30. Clin Cancer Res. 2014. PMID: 24173541

3

Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.

Sang J, Acquaviva J, Friedland JC, Smith DL, Sequeira M, Zhang C, Jiang Q, Xue L, Lovly CM, Jimenez JP, Shaw AT, Doebele RC, He S, Bates RC, Camidge DR, Morris SW, El-Hariry I, Proia DA. Sang J, et al. Among authors: proia da. Cancer Discov. 2013 Apr;3(4):430-43. doi: 10.1158/2159-8290.CD-12-0440. Epub 2013 Mar 26. Cancer Discov. 2013. PMID: 23533265 Free PMC article. Clinical Trial.

4

Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.

Shatzer A, Ali MA, Chavez M, Dowdell K, Lee MJ, Tomita Y, El-Hariry I, Trepel JB, Proia DA, Cohen JI. Shatzer A, et al. Among authors: proia da. Leuk Lymphoma. 2017 Apr;58(4):923-931. doi: 10.1080/10428194.2016.1213823. Epub 2016 Aug 11. Leuk Lymphoma. 2017. PMID: 27686857 Free PMC article.

5

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib.

Landmann H, Proia DA, He S, Ogawa LS, Kramer F, Beißbarth T, Grade M, Gaedcke J, Ghadimi M, Moll U, Dobbelstein M. Landmann H, et al. Among authors: proia da. Cell Death Dis. 2014 Sep 11;5(9):e1411. doi: 10.1038/cddis.2014.378. Cell Death Dis. 2014. PMID: 25210794 Free PMC article.

6

Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer.

Agyeman AS, Jun WJ, Proia DA, Kim CR, Skor MN, Kocherginsky M, Conzen SD. Agyeman AS, et al. Among authors: proia da. Horm Cancer. 2016 Apr;7(2):114-26. doi: 10.1007/s12672-016-0251-8. Epub 2016 Feb 8. Horm Cancer. 2016. PMID: 26858237 Free PMC article.

7

Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.

Wang Y, Liu H, Diao L, Potter A, Zhang J, Qiao Y, Wang J, Proia DA, Tailor R, Komaki R, Lin SH. Wang Y, et al. Among authors: proia da. Clin Cancer Res. 2016 Dec 1;22(23):5876-5886. doi: 10.1158/1078-0432.CCR-15-2190. Epub 2016 Jun 28. Clin Cancer Res. 2016. PMID: 27354472 Free PMC article.

8

Ganetespib radiosensitization for liver cancer therapy.

Chettiar ST, Malek R, Annadanam A, Nugent KM, Kato Y, Wang H, Cades JA, Taparra K, Belcaid Z, Ballew M, Manmiller S, Proia D, Lim M, Anders RA, Herman JM, Tran PT. Chettiar ST, et al. Cancer Biol Ther. 2016 Apr 2;17(4):457-66. doi: 10.1080/15384047.2016.1156258. Cancer Biol Ther. 2016. PMID: 26980196 Free PMC article.

9

Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.

Friedland JC, Smith DL, Sang J, Acquaviva J, He S, Zhang C, Proia DA. Friedland JC, et al. Among authors: proia da. Invest New Drugs. 2014 Feb;32(1):14-24. doi: 10.1007/s10637-013-9971-6. Epub 2013 May 18. Invest New Drugs. 2014. PMID: 23686707 Free PMC article.

10

The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.

He S, Smith DL, Sequeira M, Sang J, Bates RC, Proia DA. He S, et al. Among authors: proia da. Invest New Drugs. 2014 Aug;32(4):577-86. doi: 10.1007/s10637-014-0095-4. Epub 2014 Apr 1. Invest New Drugs. 2014. PMID: 24682747 Free PMC article.

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