Gil-Fariña I - Search Results

1

IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.

Gil-Fariña I, Di Scala M, Vanrell L, Olagüe C, Vales A, High KA, Prieto J, Mingozzi F, Gonzalez-Aseguinolaza G. Gil-Fariña I, et al. PLoS One. 2013 Jul 2;8(7):e67748. doi: 10.1371/journal.pone.0067748. Print 2013. PLoS One. 2013. PMID: 23844082 Free PMC article.

2

Development of a liver-specific Tet-on inducible system for AAV vectors and its application in the treatment of liver cancer.

Vanrell L, Di Scala M, Blanco L, Otano I, Gil-Farina I, Baldim V, Paneda A, Berraondo P, Beattie SG, Chtarto A, Tenenbaum L, Prieto J, Gonzalez-Aseguinolaza G. Vanrell L, et al. Mol Ther. 2011 Jul;19(7):1245-53. doi: 10.1038/mt.2011.37. Epub 2011 Mar 1. Mol Ther. 2011. PMID: 21364542 Free PMC article.

3

Chronic exposure to IFNα drives medullar lymphopoiesis towards T-cell differentiation in mice.

Di Scala M, Gil-Fariña I, Vanrell L, Sánchez-Bayona R, Alignani D, Olagüe C, Vales A, Berraondo P, Prieto J, González-Aseguinolaza G. Di Scala M, et al. Haematologica. 2015 Aug;100(8):1014-22. doi: 10.3324/haematol.2014.115410. Epub 2015 Feb 24. Haematologica. 2015. PMID: 25715405 Free PMC article.

4

Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients.

Gil-Farina I, Fronza R, Kaeppel C, Lopez-Franco E, Ferreira V, D'Avola D, Benito A, Prieto J, Petry H, Gonzalez-Aseguinolaza G, Schmidt M. Gil-Farina I, et al. Mol Ther. 2016 Jun;24(6):1100-1105. doi: 10.1038/mt.2016.52. Epub 2016 Mar 7. Mol Ther. 2016. PMID: 26948440 Free PMC article.

5

Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria.

D'Avola D, López-Franco E, Sangro B, Pañeda A, Grossios N, Gil-Farina I, Benito A, Twisk J, Paz M, Ruiz J, Schmidt M, Petry H, Harper P, de Salamanca RE, Fontanellas A, Prieto J, González-Aseguinolaza G. D'Avola D, et al. J Hepatol. 2016 Oct;65(4):776-783. doi: 10.1016/j.jhep.2016.05.012. Epub 2016 May 17. J Hepatol. 2016. PMID: 27212246 Free article. Clinical Trial.

6

Identification of IFN-γ-producing T cells as the main mediators of the side effects associated to mouse interleukin-15 sustained exposure.

Di Scala M, Gil-Fariña I, Olagüe C, Vales A, Sobrevals L, Fortes P, Corbacho D, González-Aseguinolaza G. Di Scala M, et al. Oncotarget. 2016 Aug 2;7(31):49008-49026. doi: 10.18632/oncotarget.10264. Oncotarget. 2016. PMID: 27356750 Free PMC article.

7

Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice.

Di Scala M, Otano I, Gil-Fariña I, Vanrell L, Hommel M, Olagüe C, Vales A, Galarraga M, Guembe L, Ortiz de Solorzano C, Ghosh I, Maini MK, Prieto J, González-Aseguinolaza G. Di Scala M, et al. J Virol. 2016 Sep 12;90(19):8563-74. doi: 10.1128/JVI.01030-16. Print 2016 Oct 1. J Virol. 2016. PMID: 27440883 Free PMC article.

8

Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis.

Gil-Farina I, Di Scala M, Salido E, López-Franco E, Rodríguez-García E, Blasi M, Merino J, Aldabe R, Prieto J, Gonzalez-Aseguinolaza G. Gil-Farina I, et al. J Immunol. 2016 Sep 15;197(6):2145-56. doi: 10.4049/jimmunol.1600228. Epub 2016 Aug 10. J Immunol. 2016. PMID: 27511737

9

AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production.

Rodriguez-Garcia E, Zabaleta N, Gil-Farina I, Gonzalez-Aparicio M, Echeverz M, Bähre H, Solano C, Lasa I, Gonzalez-Aseguinolaza G, Hommel M. Rodriguez-Garcia E, et al. Among authors: gil farina i. J Immunol. 2021 Jan 15;206(2):376-385. doi: 10.4049/jimmunol.2000953. Epub 2020 Dec 9. J Immunol. 2021. PMID: 33298616

10

In Utero Transfer of Adeno-Associated Viral Vectors Produces Long-Term Factor IX Levels in a Cynomolgus Macaque Model.

Mattar CNZ, Gil-Farina I, Rosales C, Johana N, Tan YYW, McIntosh J, Kaeppel C, Waddington SN, Biswas A, Choolani M, Schmidt M, Nathwani AC, Chan JKY. Mattar CNZ, et al. Mol Ther. 2017 Aug 2;25(8):1843-1853. doi: 10.1016/j.ymthe.2017.04.003. Epub 2017 Apr 24. Mol Ther. 2017. PMID: 28462816 Free PMC article.

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