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The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.
Washburn DG, Holt DA, Dodson J, McAtee JJ, Terrell LR, Barton L, Manns S, Waszkiewicz A, Pritchard C, Gillie DJ, Morrow DM, Davenport EA, Lozinskaya IM, Guss J, Basilla JB, Negron LK, Klein M, Willette RN, Fries RE, Jensen TC, Xu X, Schnackenberg CG, Marino JP Jr. Washburn DG, et al. Among authors: gillie dj. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84. doi: 10.1016/j.bmcl.2013.06.047. Epub 2013 Jun 26. Bioorg Med Chem Lett. 2013. PMID: 23886683
Modulation of Ligand-Gated Glycine Receptors Via Functional Monoclonal Antibodies.
Simard JR, Michelsen K, Wang Y, Yang C, Youngblood B, Grubinska B, Taborn K, Gillie DJ, Cook K, Chung K, Long AM, Hall BE, Shaffer PL, Foti RS, Gingras J. Simard JR, et al. Among authors: gillie dj. J Pharmacol Exp Ther. 2022 Oct;383(1):56-69. doi: 10.1124/jpet.121.001026. Epub 2022 Aug 4. J Pharmacol Exp Ther. 2022. PMID: 35926871