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Development of LB244, an Irreversible STING Antagonist.
Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Barasa L, et al. Among authors: humphries f. J Am Chem Soc. 2023 Sep 20;145(37):20273-20288. doi: 10.1021/jacs.3c03637. Epub 2023 Sep 11. J Am Chem Soc. 2023. PMID: 37695732 Free PMC article.
CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates.
Fitzgerald K, Chen Y, Lei X, Jiang Z, Humphries F, Mustone N, Ramos I, Mutetwa T, Fernandez-Sesma A. Fitzgerald K, et al. Among authors: humphries f. Res Sq [Preprint]. 2022 May 2:rs.3.rs-1576788. doi: 10.21203/rs.3.rs-1576788/v1. Res Sq. 2022. Update in: Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2308355120. doi: 10.1073/pnas.2308355120 PMID: 35547851 Free PMC article. Updated. Preprint.
Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.
Chen Y, Lei X, Jiang Z, Humphries F, Parsi KM, Mustone NJ, Ramos I, Mutetwa T, Fernandez-Sesma A, Maehr R, Caffrey DR, Fitzgerald KA. Chen Y, et al. Among authors: humphries f. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2308355120. doi: 10.1073/pnas.2308355120. Epub 2023 Nov 14. Proc Natl Acad Sci U S A. 2023. PMID: 37963251 Free PMC article.
Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses.
Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Rosales AR, Molinaro A, Moynagh PN, Lajoie GA, Valvano MA. Hanuszkiewicz A, et al. Among authors: humphries f. J Biol Chem. 2014 Jul 4;289(27):19231-44. doi: 10.1074/jbc.M114.562603. Epub 2014 May 19. J Biol Chem. 2014. PMID: 24841205 Free PMC article.
ECSIT is a critical limiting factor for cardiac function.
Xu L, Humphries F, Delagic N, Wang B, Holland A, Edgar KS, Hombrebueno JR, Stolz DB, Oleszycka E, Rodgers AM, Glezeva N, McDonald K, Watson CJ, Ledwidge MT, Ingram RJ, Grieve DJ, Moynagh PN. Xu L, et al. Among authors: humphries f. JCI Insight. 2021 Jun 22;6(12):e142801. doi: 10.1172/jci.insight.142801. JCI Insight. 2021. PMID: 34032637 Free PMC article.
49 results