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Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. Materazzi S, et al. Among authors: trevisan g. Pain. 2013 Dec;154(12):2750-2758. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8. Pain. 2013. PMID: 23933184 Free PMC article.
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. Nassini R, et al. Among authors: trevisan g. FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438. Epub 2010 Aug 18. FASEB J. 2010. PMID: 20720158
The TRPA1 channel in migraine mechanism and treatment.
Benemei S, Fusi C, Trevisan G, Geppetti P. Benemei S, et al. Among authors: trevisan g. Br J Pharmacol. 2014 May;171(10):2552-67. doi: 10.1111/bph.12512. Br J Pharmacol. 2014. PMID: 24206166 Free PMC article. Review.
TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout.
Trevisan G, Hoffmeister C, Rossato MF, Oliveira SM, Silva MA, Silva CR, Fusi C, Tonello R, Minocci D, Guerra GP, Materazzi S, Nassini R, Geppetti P, Ferreira J. Trevisan G, et al. Free Radic Biol Med. 2014 Jul;72:200-9. doi: 10.1016/j.freeradbiomed.2014.04.021. Epub 2014 Apr 26. Free Radic Biol Med. 2014. PMID: 24780252 Free article.
The involvement of the TRPA1 receptor in a mouse model of sympathetically maintained neuropathic pain.
Pinheiro Fde V, Villarinho JG, Silva CR, Oliveira SM, Pinheiro Kde V, Petri D, Rossato MF, Guerra GP, Trevisan G, Antonello Rubin M, Geppetti P, Ferreira J, André E. Pinheiro Fde V, et al. Among authors: trevisan g. Eur J Pharmacol. 2015 Jan 15;747:105-13. doi: 10.1016/j.ejphar.2014.11.039. Epub 2014 Dec 10. Eur J Pharmacol. 2015. PMID: 25498793 Free article.
Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice.
De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl'Innocenti D, Marone IM, Ferreira J, Li Puma S, Benemei S, Trevisan G, Souza Monteiro de Araújo D, Patacchini R, Bunnett NW, Geppetti P. De Logu F, et al. Among authors: trevisan g. Nat Commun. 2017 Dec 1;8(1):1887. doi: 10.1038/s41467-017-01739-2. Nat Commun. 2017. PMID: 29192190 Free PMC article.
420 results