Shepherd PR - Search Results

1

Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.

Buchanan CM, Dickson JM, Lee WJ, Guthridge MA, Kendall JD, Shepherd PR. Buchanan CM, et al. Among authors: shepherd pr. PLoS One. 2013 Aug 1;8(8):e71337. doi: 10.1371/journal.pone.0071337. Print 2013. PLoS One. 2013. PMID: 23936502 Free PMC article.

2

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Chaussade C, Rewcastle GW, Kendall JD, Denny WA, Cho K, Grønning LM, Chong ML, Anagnostou SH, Jackson SP, Daniele N, Shepherd PR. Chaussade C, et al. Among authors: shepherd pr. Biochem J. 2007 Jun 15;404(3):449-58. doi: 10.1042/BJ20070003. Biochem J. 2007. PMID: 17362206 Free PMC article.

3

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

Kendall JD, Rewcastle GW, Frederick R, Mawson C, Denny WA, Marshall ES, Baguley BC, Chaussade C, Jackson SP, Shepherd PR. Kendall JD, et al. Among authors: shepherd pr. Bioorg Med Chem. 2007 Dec 15;15(24):7677-87. doi: 10.1016/j.bmc.2007.08.062. Epub 2007 Sep 4. Bioorg Med Chem. 2007. PMID: 17869522

4

Investigating the role of class-IA PI 3-kinase isoforms in adipocyte differentiation.

Kim JE, Shepherd PR, Chaussade C. Kim JE, et al. Among authors: shepherd pr. Biochem Biophys Res Commun. 2009 Feb 20;379(4):830-4. doi: 10.1016/j.bbrc.2008.12.089. Epub 2008 Dec 27. Biochem Biophys Res Commun. 2009. PMID: 19114029

5

Functional differences between two classes of oncogenic mutation in the PIK3CA gene.

Chaussade C, Cho K, Mawson C, Rewcastle GW, Shepherd PR. Chaussade C, et al. Among authors: shepherd pr. Biochem Biophys Res Commun. 2009 Apr 17;381(4):577-81. doi: 10.1016/j.bbrc.2009.02.081. Epub 2009 Feb 20. Biochem Biophys Res Commun. 2009. PMID: 19233141

6

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

Frédérick R, Mawson C, Kendall JD, Chaussade C, Rewcastle GW, Shepherd PR, Denny WA. Frédérick R, et al. Among authors: shepherd pr. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. doi: 10.1016/j.bmcl.2009.08.087. Epub 2009 Aug 29. Bioorg Med Chem Lett. 2009. PMID: 19748269

7

Evidence for a role for the p110-alpha isoform of PI3K in skeletal function.

Grey A, Chaussade C, Empson V, Lin JM, Watson M, O'Sullivan S, Rewcastle G, Naot D, Cornish J, Shepherd P. Grey A, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):564-9. doi: 10.1016/j.bbrc.2009.11.099. Epub 2009 Nov 24. Biochem Biophys Res Commun. 2010. PMID: 19931507

8

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.

Jamieson S, Flanagan JU, Kolekar S, Buchanan C, Kendall JD, Lee WJ, Rewcastle GW, Denny WA, Singh R, Dickson J, Baguley BC, Shepherd PR. Jamieson S, et al. Among authors: shepherd pr. Biochem J. 2011 Aug 15;438(1):53-62. doi: 10.1042/BJ20110502. Biochem J. 2011. PMID: 21668414 Free PMC article.

9

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

Rewcastle GW, Gamage SA, Flanagan JU, Frederick R, Denny WA, Baguley BC, Kestell P, Singh R, Kendall JD, Marshall ES, Lill CL, Lee WJ, Kolekar S, Buchanan CM, Jamieson SM, Shepherd PR. Rewcastle GW, et al. Among authors: shepherd pr. J Med Chem. 2011 Oct 27;54(20):7105-26. doi: 10.1021/jm200688y. Epub 2011 Sep 27. J Med Chem. 2011. PMID: 21882832

10

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo.

Smith GC, Ong WK, Rewcastle GW, Kendall JD, Han W, Shepherd PR. Smith GC, et al. Among authors: shepherd pr. Biochem J. 2012 Feb 15;442(1):161-9. doi: 10.1042/BJ20111913. Biochem J. 2012. PMID: 22142257 Free PMC article.

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