Upton PD - Search Results

1

BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia.

Wooderchak-Donahue WL, McDonald J, O'Fallon B, Upton PD, Li W, Roman BL, Young S, Plant P, Fülöp GT, Langa C, Morrell NW, Botella LM, Bernabeu C, Stevenson DA, Runo JR, Bayrak-Toydemir P. Wooderchak-Donahue WL, et al. Among authors: upton pd. Am J Hum Genet. 2013 Sep 5;93(3):530-7. doi: 10.1016/j.ajhg.2013.07.004. Epub 2013 Aug 22. Am J Hum Genet. 2013. PMID: 23972370 Free PMC article.

2

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor.

Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW. Atkinson C, et al. Among authors: upton pd. Circulation. 2002 Apr 9;105(14):1672-8. doi: 10.1161/01.cir.0000012754.72951.3d. Circulation. 2002. PMID: 11940546

3

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.

Rudarakanchana N, Flanagan JA, Chen H, Upton PD, Machado R, Patel D, Trembath RC, Morrell NW. Rudarakanchana N, et al. Among authors: upton pd. Hum Mol Genet. 2002 Jun 15;11(13):1517-25. doi: 10.1093/hmg/11.13.1517. Hum Mol Genet. 2002. PMID: 12045205

4

Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase.

Sobolewski A, Jourdan KB, Upton PD, Long L, Morrell NW. Sobolewski A, et al. Among authors: upton pd. Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L352-9. doi: 10.1152/ajplung.00270.2003. Epub 2004 Apr 23. Am J Physiol Lung Cell Mol Physiol. 2004. PMID: 15107293 Free article.

5

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways.

Jeffery TK, Upton PD, Trembath RC, Morrell NW. Jeffery TK, et al. Among authors: upton pd. Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L370-8. doi: 10.1152/ajplung.00242.2004. Epub 2004 Oct 29. Am J Physiol Lung Cell Mol Physiol. 2005. PMID: 15516492 Free article.

6

Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW. Yang X, et al. Among authors: upton pd. Circ Res. 2005 May 27;96(10):1053-63. doi: 10.1161/01.RES.0000166926.54293.68. Epub 2005 Apr 21. Circ Res. 2005. PMID: 15845886

7

Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells.

Upton PD, Long L, Trembath RC, Morrell NW. Upton PD, et al. Mol Pharmacol. 2008 Feb;73(2):539-52. doi: 10.1124/mol.107.041673. Epub 2007 Nov 7. Mol Pharmacol. 2008. PMID: 17989347

8

Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension.

Yang J, Davies RJ, Southwood M, Long L, Yang X, Sobolewski A, Upton PD, Trembath RC, Morrell NW. Yang J, et al. Among authors: upton pd. Circ Res. 2008 May 23;102(10):1212-21. doi: 10.1161/CIRCRESAHA.108.173567. Epub 2008 Apr 24. Circ Res. 2008. PMID: 18436795

9

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue.

Sobolewski A, Rudarakanchana N, Upton PD, Yang J, Crilley TK, Trembath RC, Morrell NW. Sobolewski A, et al. Among authors: upton pd. Hum Mol Genet. 2008 Oct 15;17(20):3180-90. doi: 10.1093/hmg/ddn214. Epub 2008 Jul 21. Hum Mol Genet. 2008. PMID: 18647753

10

Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease.

Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim DK, Morrell NW. Long L, et al. Among authors: upton pd. Circulation. 2009 Feb 3;119(4):566-76. doi: 10.1161/CIRCULATIONAHA.108.821504. Epub 2009 Jan 19. Circulation. 2009. PMID: 19153267

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