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Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.
Vilums M, Zweemer AJ, Yu Z, de Vries H, Hillger JM, Wapenaar H, Bollen IA, Barmare F, Gross R, Clemens J, Krenitsky P, Brussee J, Stamos D, Saunders J, Heitman LH, Ijzerman AP. Vilums M, et al. Among authors: heitman lh. J Med Chem. 2013 Oct 10;56(19):7706-14. doi: 10.1021/jm4011737. Epub 2013 Sep 27. J Med Chem. 2013. PMID: 24028535
Synthesis and evaluation of homo-bivalent GnRHR ligands.
Bonger KM, van den Berg RJ, Heitman LH, IJzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA. Bonger KM, et al. Among authors: heitman lh. Bioorg Med Chem. 2007 Jul 15;15(14):4841-56. doi: 10.1016/j.bmc.2007.04.065. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17517510
159 results