Smith PC - Search Results

1

Targeted precise quantification of 12 human recombinant uridine-diphosphate glucuronosyl transferase 1A and 2B isoforms using nano-ultra-high-performance liquid chromatography/tandem mass spectrometry with selected reaction monitoring.

Fallon JK, Neubert H, Goosen TC, Smith PC. Fallon JK, et al. Among authors: smith pc. Drug Metab Dispos. 2013 Dec;41(12):2076-80. doi: 10.1124/dmd.113.053801. Epub 2013 Sep 17. Drug Metab Dispos. 2013. PMID: 24046331 Free PMC article.

2

Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms.

Tallman MN, Ritter JK, Smith PC. Tallman MN, et al. Among authors: smith pc. Drug Metab Dispos. 2005 Jul;33(7):977-83. doi: 10.1124/dmd.104.003491. Epub 2005 Apr 15. Drug Metab Dispos. 2005. PMID: 15833930

3

Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents.

Suzuki M, Li Y, Smith PC, Swenberg JA, Martin DE, Morris-Natschke SL, Lee KH. Suzuki M, et al. Among authors: smith pc. Drug Metab Dispos. 2005 Nov;33(11):1588-92. doi: 10.1124/dmd.105.004218. Epub 2005 Aug 8. Drug Metab Dispos. 2005. PMID: 16087699

4

Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3',3'-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma.

Wen Z, Stern ST, Martin DE, Lee KH, Smith PC. Wen Z, et al. Among authors: smith pc. Drug Metab Dispos. 2006 Sep;34(9):1436-42. doi: 10.1124/dmd.106.009233. Epub 2006 Jun 2. Drug Metab Dispos. 2006. PMID: 16751262

5

Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences.

Wen Z, Martin DE, Bullock P, Lee KH, Smith PC. Wen Z, et al. Among authors: smith pc. Drug Metab Dispos. 2007 Mar;35(3):440-8. doi: 10.1124/dmd.106.012815. Epub 2006 Dec 6. Drug Metab Dispos. 2007. PMID: 17151190

6

UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics.

Wen Z, Tallman MN, Ali SY, Smith PC. Wen Z, et al. Among authors: smith pc. Drug Metab Dispos. 2007 Mar;35(3):371-80. doi: 10.1124/dmd.106.012732. Epub 2006 Dec 6. Drug Metab Dispos. 2007. PMID: 17151191

7

Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.

Wen Z, Dumas TE, Schrieber SJ, Hawke RL, Fried MW, Smith PC. Wen Z, et al. Among authors: smith pc. Drug Metab Dispos. 2008 Jan;36(1):65-72. doi: 10.1124/dmd.107.017566. Epub 2007 Oct 3. Drug Metab Dispos. 2008. PMID: 17913795

8

Androgen regulation of renal uridine diphosphoglucuronosyltransferase 1A1 in rats.

Stern ST, Tallman MN, Miles KK, Ritter JK, Smith PC. Stern ST, et al. Among authors: smith pc. Drug Metab Dispos. 2008 Sep;36(9):1737-9. doi: 10.1124/dmd.108.020610. Epub 2008 May 30. Drug Metab Dispos. 2008. PMID: 18515331

9

Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) enzyme isoforms 1A1 and 1A6 by tandem LC-MS.

Fallon JK, Harbourt DE, Maleki SH, Kessler FK, Ritter JK, Smith PC. Fallon JK, et al. Among authors: smith pc. Drug Metab Lett. 2008 Aug;2(3):210-22. doi: 10.2174/187231208785425764. Drug Metab Lett. 2008. PMID: 19356096

10

Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry.

Harbourt DE, Fallon JK, Ito S, Baba T, Ritter JK, Glish GL, Smith PC. Harbourt DE, et al. Among authors: smith pc. Anal Chem. 2012 Jan 3;84(1):98-105. doi: 10.1021/ac201704a. Epub 2011 Dec 5. Anal Chem. 2012. PMID: 22050083 Free PMC article.

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