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Biophysical properties of the clinical-stage antibody landscape.
Jain T, Sun T, Durand S, Hall A, Houston NR, Nett JH, Sharkey B, Bobrowicz B, Caffry I, Yu Y, Cao Y, Lynaugh H, Brown M, Baruah H, Gray LT, Krauland EM, Xu Y, Vásquez M, Wittrup KD. Jain T, et al. Among authors: wittrup kd. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):944-949. doi: 10.1073/pnas.1616408114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096333 Free PMC article.
A switchable yeast display/secretion system.
Van Deventer JA, Kelly RL, Rajan S, Wittrup KD, Sidhu SS. Van Deventer JA, et al. Among authors: wittrup kd. Protein Eng Des Sel. 2015 Oct;28(10):317-25. doi: 10.1093/protein/gzv043. Epub 2015 Sep 1. Protein Eng Des Sel. 2015. PMID: 26333274 Free PMC article.
Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins.
Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD. Yang NJ, et al. Among authors: wittrup kd. Nucleic Acids Res. 2017 Jul 27;45(13):7602-7614. doi: 10.1093/nar/gkx546. Nucleic Acids Res. 2017. PMID: 28641400 Free PMC article.
Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM. Bornholdt ZA, et al. Among authors: wittrup kd. Science. 2016 Mar 4;351(6277):1078-83. doi: 10.1126/science.aad5788. Epub 2016 Feb 18. Science. 2016. PMID: 26912366 Free PMC article.
Five birds, one stone: neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody.
Rouha H, Badarau A, Visram ZC, Battles MB, Prinz B, Magyarics Z, Nagy G, Mirkina I, Stulik L, Zerbs M, Jägerhofer M, Maierhofer B, Teubenbacher A, Dolezilkova I, Gross K, Banerjee S, Zauner G, Malafa S, Zmajkovic J, Maier S, Mabry R, Krauland E, Wittrup KD, Gerngross TU, Nagy E. Rouha H, et al. Among authors: wittrup kd. MAbs. 2015;7(1):243-54. doi: 10.4161/19420862.2014.985132. MAbs. 2015. PMID: 25523282 Free PMC article.
223 results