Spasov KA - Search Results

1

First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling.

Sharma H, Landau MJ, Vargo MA, Spasov KA, Anderson KS. Sharma H, et al. Among authors: spasov ka. Biochemistry. 2013 Oct 15;52(41):7305-7317. doi: 10.1021/bi400576t. Epub 2013 Oct 3. Biochemistry. 2013. PMID: 24053355 Free PMC article.

2

Eastern extension of azoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase; cyano group alternatives.

Leung CS, Zeevaart JG, Domaoal RA, Bollini M, Thakur VV, Spasov KA, Anderson KS, Jorgensen WL. Leung CS, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2485-8. doi: 10.1016/j.bmcl.2010.03.006. Epub 2010 Mar 4. Bioorg Med Chem Lett. 2010. PMID: 20304641 Free PMC article.

3

Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase.

Jorgensen WL, Bollini M, Thakur VV, Domaoal RA, Spasov KA, Anderson KS. Jorgensen WL, et al. Among authors: spasov ka. J Am Chem Soc. 2011 Oct 5;133(39):15686-96. doi: 10.1021/ja2058583. Epub 2011 Sep 9. J Am Chem Soc. 2011. PMID: 21853995 Free PMC article.

4

Computationally-guided optimization of a docking hit to yield catechol diethers as potent anti-HIV agents.

Bollini M, Domaoal RA, Thakur VV, Gallardo-Macias R, Spasov KA, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. J Med Chem. 2011 Dec 22;54(24):8582-91. doi: 10.1021/jm201134m. Epub 2011 Nov 29. J Med Chem. 2011. PMID: 22081993 Free PMC article.

5

Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase.

Ekkati AR, Bollini M, Domaoal RA, Spasov KA, Anderson KS, Jorgensen WL. Ekkati AR, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1565-8. doi: 10.1016/j.bmcl.2011.12.132. Epub 2012 Jan 5. Bioorg Med Chem Lett. 2012. PMID: 22269110 Free PMC article.

6

Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency.

Bollini M, Gallardo-Macias R, Spasov KA, Tirado-Rives J, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1110-3. doi: 10.1016/j.bmcl.2012.11.115. Epub 2012 Dec 12. Bioorg Med Chem Lett. 2013. PMID: 23298809 Free PMC article.

7

Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility.

Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5209-12. doi: 10.1016/j.bmcl.2013.06.093. Epub 2013 Jul 8. Bioorg Med Chem Lett. 2013. PMID: 23899617 Free PMC article.

8

Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.

Bollini M, Cisneros JA, Spasov KA, Anderson KS, Jorgensen WL. Bollini M, et al. Among authors: spasov ka. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5213-6. doi: 10.1016/j.bmcl.2013.06.091. Epub 2013 Jul 8. Bioorg Med Chem Lett. 2013. PMID: 23937980 Free PMC article.

9

Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group.

Lee WG, Gallardo-Macias R, Frey KM, Spasov KA, Bollini M, Anderson KS, Jorgensen WL. Lee WG, et al. Among authors: spasov ka. J Am Chem Soc. 2013 Nov 6;135(44):16705-13. doi: 10.1021/ja408917n. Epub 2013 Oct 24. J Am Chem Soc. 2013. PMID: 24151856 Free PMC article.

10

Quasi-Biomimetic Ring Contraction Catalyzed by a Cysteine-Based Nucleophile: Total Synthesis of Sch-642305, Some Analogs and their Putative anti-HIV Activities.

Dermenci A, Selig PS, Domaoal RA, Spasov KA, Anderson KS, Miller SJ. Dermenci A, et al. Among authors: spasov ka. Chem Sci. 2011 Aug 1;2(8):10.1039/C1SC00221J. doi: 10.1039/C1SC00221J. Chem Sci. 2011. PMID: 24179673 Free PMC article.

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