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A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells.
Honisch S, Alkahtani S, Kounenidakis M, Liu G, Alarifi S, Al-Yahya H, Dimas K, AlKahtane AA, Prousis KC, Al-Dahmash B, Calogeropoulou T, Alevizopoulos K, Lang F, Stournaras C. Honisch S, et al. Among authors: lang f. Anticancer Agents Med Chem. 2014;14(8):1161-8. doi: 10.2174/1871520614666140618114418. Anticancer Agents Med Chem. 2014. PMID: 24942548
Na+/K+ ATPase inhibitors in cancer.
Alevizopoulos K, Calogeropoulou T, Lang F, Stournaras C. Alevizopoulos K, et al. Among authors: lang f. Curr Drug Targets. 2014;15(10):988-1000. Curr Drug Targets. 2014. PMID: 25198786 Review.
Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor.
Alevizopoulos K, Dimas K, Papadopoulou N, Schmidt EM, Tsapara A, Alkahtani S, Honisch S, Prousis KC, Alarifi S, Calogeropoulou T, Lang F, Stournaras C. Alevizopoulos K, et al. Among authors: lang f. Oncotarget. 2016 Apr 26;7(17):24415-28. doi: 10.18632/oncotarget.8329. Oncotarget. 2016. PMID: 27027435 Free PMC article.
Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells.
Papadopoulou N, Charalampopoulos I, Anagnostopoulou V, Konstantinidis G, Föller M, Gravanis A, Alevizopoulos K, Lang F, Stournaras C. Papadopoulou N, et al. Among authors: lang f. Mol Cancer. 2008 Dec 3;7:88. doi: 10.1186/1476-4598-7-88. Mol Cancer. 2008. PMID: 19055752 Free PMC article.
Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells.
Stagno MJ, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al-Maghout T, Kallergi G, Alkahtani S, Alevizopoulos K, Dimas K, Calogeropoulou T, Warmann SW, Lang F, Schmid E, Stournaras C. Stagno MJ, et al. Among authors: lang f. Cell Physiol Biochem. 2017;42(4):1366-1376. doi: 10.1159/000479200. Epub 2017 Jul 14. Cell Physiol Biochem. 2017. PMID: 28704809 Free article.
Role of Na+/Ca2+ Exchangers in Therapy Resistance of Medulloblastoma Cells.
Pelzl L, Hosseinzadeh Z, Al-Maghout T, Singh Y, Sahu I, Bissinger R, Schmidt S, Alkahtani S, Stournaras C, Toulany M, Lang F. Pelzl L, et al. Among authors: lang f. Cell Physiol Biochem. 2017;42(3):1240-1251. doi: 10.1159/000478953. Epub 2017 Jul 3. Cell Physiol Biochem. 2017. PMID: 28683437 Free article.
2,579 results