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Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy.
Iglesias DA, Yates MS, van der Hoeven D, Rodkey TL, Zhang Q, Co NN, Burzawa J, Chigurupati S, Celestino J, Bowser J, Broaddus R, Hancock JF, Schmandt R, Lu KH. Iglesias DA, et al. Among authors: zhang q. Mol Cancer Ther. 2013 Dec;12(12):2847-56. doi: 10.1158/1535-7163.MCT-13-0439. Epub 2013 Sep 27. Mol Cancer Ther. 2013. PMID: 24077915 Free PMC article.
Enhanced estrogen-induced proliferation in obese rat endometrium.
Zhang Q, Shen Q, Celestino J, Milam MR, Westin SN, Lacour RA, Meyer LA, Shipley GL, Davies PJ, Deng L, McCampbell AS, Broaddus RR, Lu KH. Zhang Q, et al. Am J Obstet Gynecol. 2009 Feb;200(2):186.e1-8. doi: 10.1016/j.ajog.2008.08.064. Am J Obstet Gynecol. 2009. PMID: 19185100 Free PMC article.
Chemopreventive effects of metformin on obesity-associated endometrial proliferation.
Zhang Q, Celestino J, Schmandt R, McCampbell AS, Urbauer DL, Meyer LA, Burzawa JK, Huang M, Yates MS, Iglesias D, Broaddus RR, Lu KH. Zhang Q, et al. Am J Obstet Gynecol. 2013 Jul;209(1):24.e1-24.e12. doi: 10.1016/j.ajog.2013.03.008. Epub 2013 Mar 15. Am J Obstet Gynecol. 2013. PMID: 23500454 Free PMC article.
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Slomovitz BM, Jiang Y, Yates MS, Soliman PT, Johnston T, Nowakowski M, Levenback C, Zhang Q, Ring K, Munsell MF, Gershenson DM, Lu KH, Coleman RL. Slomovitz BM, et al. Among authors: zhang q. J Clin Oncol. 2015 Mar 10;33(8):930-6. doi: 10.1200/JCO.2014.58.3401. Epub 2015 Jan 26. J Clin Oncol. 2015. PMID: 25624430 Free PMC article. Clinical Trial.
Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study.
Soliman PT, Zhang Q, Broaddus RR, Westin SN, Iglesias D, Munsell MF, Schmandt R, Yates M, Ramondetta L, Lu KH. Soliman PT, et al. Among authors: zhang q. Gynecol Oncol. 2016 Dec;143(3):466-471. doi: 10.1016/j.ygyno.2016.10.011. Epub 2016 Oct 13. Gynecol Oncol. 2016. PMID: 27745917 Free PMC article.
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