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Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolisers compared with twice-daily omeprazole, rabeprazole or lansoprazole.
Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T. Sahara S, et al. Among authors: miyajima h. Aliment Pharmacol Ther. 2013 Nov;38(9):1129-37. doi: 10.1111/apt.12492. Epub 2013 Sep 16. Aliment Pharmacol Ther. 2013. PMID: 24099474 Clinical Trial.
Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.
Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T. Uotani T, et al. Among authors: miyajima h. Clin Gastroenterol Hepatol. 2012 Aug;10(8):879-885.e2. doi: 10.1016/j.cgh.2012.04.016. Epub 2012 Apr 25. Clin Gastroenterol Hepatol. 2012. PMID: 22542748 Clinical Trial.
Antiplatelet drugs are a risk factor for esophageal mucosal injury.
Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T. Sugimoto M, et al. Among authors: miyajima h. Digestion. 2013;87(4):281-9. doi: 10.1159/000350438. Epub 2013 Jun 13. Digestion. 2013. PMID: 23774797
Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine.
Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T. Uotani T, et al. Among authors: miyajima h. J Clin Pharmacol. 2014 Aug;54(8):858-64. doi: 10.1002/jcph.284. Epub 2014 Mar 21. J Clin Pharmacol. 2014. PMID: 24615745 Clinical Trial.
One-day front-loading with four doses of rabeprazole followed by a standard twice-daily regimen provides sufficient acid inhibition in extensive metabolizers of CYP2C19.
Kagami T, Sugimoto M, Ichikawa H, Sahara S, Uotani T, Yamade M, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K, Miyajima H, Furuta T. Kagami T, et al. Among authors: miyajima h. Eur J Clin Pharmacol. 2015 Dec;71(12):1467-75. doi: 10.1007/s00228-015-1941-9. Epub 2015 Oct 2. Eur J Clin Pharmacol. 2015. PMID: 26427705 Clinical Trial.
376 results