Empting M - Search Results

1

Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures.

Storz MP, Brengel C, Weidel E, Hoffmann M, Hollemeyer K, Steinbach A, Müller R, Empting M, Hartmann RW. Storz MP, et al. Among authors: empting m. ACS Chem Biol. 2013 Dec 20;8(12):2794-801. doi: 10.1021/cb400530d. Epub 2013 Oct 25. ACS Chem Biol. 2013. PMID: 24099650

2

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors.

Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann RW, Engel M. Schmitt C, et al. Among authors: empting m. PLoS One. 2014 Mar 27;9(3):e87851. doi: 10.1371/journal.pone.0087851. eCollection 2014. PLoS One. 2014. PMID: 24676346 Free PMC article.

3

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.

Hutter MC, Brengel C, Negri M, Henn C, Zimmer C, Hartmann RW, Empting M, Steinbach A. Hutter MC, et al. Among authors: empting m. J Mol Model. 2014 Jun;20(6):2255. doi: 10.1007/s00894-014-2255-z. Epub 2014 May 15. J Mol Model. 2014. PMID: 24842325

4

From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa.

Storz MP, Allegretta G, Kirsch B, Empting M, Hartmann RW. Storz MP, et al. Among authors: empting m. Org Biomol Chem. 2014 Aug 28;12(32):6094-104. doi: 10.1039/c4ob00707g. Epub 2014 Jun 9. Org Biomol Chem. 2014. PMID: 24909330

5

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker.

Abdelsamie AS, Bey E, Hanke N, Empting M, Hartmann RW, Frotscher M. Abdelsamie AS, et al. Among authors: empting m. Eur J Med Chem. 2014 Jul 23;82:394-406. doi: 10.1016/j.ejmech.2014.05.074. Epub 2014 Jun 3. Eur J Med Chem. 2014. PMID: 24929290

6

Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD.

Allegretta G, Weidel E, Empting M, Hartmann RW. Allegretta G, et al. Among authors: empting m. Eur J Med Chem. 2015 Jan 27;90:351-9. doi: 10.1016/j.ejmech.2014.11.055. Epub 2014 Nov 27. Eur J Med Chem. 2015. PMID: 25437621 Free article.

7

Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

Weidel E, Negri M, Empting M, Hinsberger S, Hartmann RW. Weidel E, et al. Among authors: empting m. Future Med Chem. 2014;6(18):2057-72. doi: 10.4155/fmc.14.142. Future Med Chem. 2014. PMID: 25531968

8

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa.

Sahner JH, Empting M, Kamal A, Weidel E, Groh M, Börger C, Hartmann RW. Sahner JH, et al. Among authors: empting m. Eur J Med Chem. 2015;96:14-21. doi: 10.1016/j.ejmech.2015.04.007. Epub 2015 Apr 6. Eur J Med Chem. 2015. PMID: 25874327

9

Steering the azido-tetrazole equilibrium of 4-azidopyrimidines via substituent variation - implications for drug design and azide-alkyne cycloadditions.

Thomann A, Zapp J, Hutter M, Empting M, Hartmann RW. Thomann A, et al. Among authors: empting m. Org Biomol Chem. 2015 Nov 21;13(43):10620-30. doi: 10.1039/c5ob01006c. Org Biomol Chem. 2015. PMID: 26340222

10

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors.

Fittler H, Depp A, Avrutina O, Dahms SO, Than ME, Empting M, Kolmar H. Fittler H, et al. Among authors: empting m. Chembiochem. 2015 Nov;16(17):2441-4. doi: 10.1002/cbic.201500447. Epub 2015 Oct 19. Chembiochem. 2015. PMID: 26426719

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