Hartmann RW - Search Results

1

Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures.

Storz MP, Brengel C, Weidel E, Hoffmann M, Hollemeyer K, Steinbach A, Müller R, Empting M, Hartmann RW. Storz MP, et al. Among authors: hartmann rw. ACS Chem Biol. 2013 Dec 20;8(12):2794-801. doi: 10.1021/cb400530d. Epub 2013 Oct 25. ACS Chem Biol. 2013. PMID: 24099650

2

Development of a new approach for screening combinatorial libraries using MALDI-TOF-MS and HPLC-ESI-MS/MS.

Mathur S, Hassel M, Steiner F, Hollemeyer K, Hartmann RW. Mathur S, et al. Among authors: hartmann rw. J Biomol Screen. 2003 Apr;8(2):136-48. doi: 10.1177/1087057103253333. J Biomol Screen. 2003. PMID: 12844434

3

Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity.

Pistorius D, Ullrich A, Lucas S, Hartmann RW, Kazmaier U, Müller R. Pistorius D, et al. Among authors: hartmann rw. Chembiochem. 2011 Apr 11;12(6):850-3. doi: 10.1002/cbic.201100014. Epub 2011 Mar 18. Chembiochem. 2011. PMID: 21425231 No abstract available.

4

Computational investigation of the binding mode of bis(hydroxylphenyl)arenes in 17β-HSD1: molecular dynamics simulations, MM-PBSA free energy calculations, and molecular electrostatic potential maps.

Negri M, Recanatini M, Hartmann RW. Negri M, et al. Among authors: hartmann rw. J Comput Aided Mol Des. 2011 Sep;25(9):795-811. doi: 10.1007/s10822-011-9464-7. Epub 2011 Aug 6. J Comput Aided Mol Des. 2011. PMID: 21822722

5

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Müsken M, Häussler S, Steinbach A, Hartmann RW. Lu C, et al. Among authors: hartmann rw. Chem Biol. 2012 Mar 23;19(3):381-90. doi: 10.1016/j.chembiol.2012.01.015. Chem Biol. 2012. PMID: 22444593

6

Catalytic enzyme activity on a biosensor chip: combination of surface plasmon resonance and mass spectrometry.

Henn C, Boettcher S, Steinbach A, Hartmann RW. Henn C, et al. Among authors: hartmann rw. Anal Biochem. 2012 Sep 1;428(1):28-30. doi: 10.1016/j.ab.2012.05.024. Epub 2012 Jun 4. Anal Biochem. 2012. PMID: 22677626

7

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Klein T, Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, Müller R, Steinbach A, Hartmann RW. Klein T, et al. Among authors: hartmann rw. ACS Chem Biol. 2012 Sep 21;7(9):1496-501. doi: 10.1021/cb300208g. Epub 2012 Jul 5. ACS Chem Biol. 2012. PMID: 22765028

8

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.

Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Müsken M, Häussler S, Steinbach A, Hartmann RW. Storz MP, et al. Among authors: hartmann rw. J Am Chem Soc. 2012 Oct 3;134(39):16143-6. doi: 10.1021/ja3072397. Epub 2012 Sep 24. J Am Chem Soc. 2012. PMID: 22992202

9

Mutation in elongation factor G confers resistance to the antibiotic argyrin in the opportunistic pathogen Pseudomonas aeruginosa.

Bielecki P, Lukat P, Hüsecken K, Dötsch A, Steinmetz H, Hartmann RW, Müller R, Häussler S. Bielecki P, et al. Among authors: hartmann rw. Chembiochem. 2012 Nov 5;13(16):2339-45. doi: 10.1002/cbic.201200479. Epub 2012 Sep 25. Chembiochem. 2012. PMID: 23011873

10

Peptide-based investigation of the Escherichia coli RNA polymerase σ(70):core interface as target site.

Hüsecken K, Negri M, Fruth M, Boettcher S, Hartmann RW, Haupenthal J. Hüsecken K, et al. Among authors: hartmann rw. ACS Chem Biol. 2013 Apr 19;8(4):758-66. doi: 10.1021/cb3005758. Epub 2013 Jan 30. ACS Chem Biol. 2013. PMID: 23330640

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