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156 results

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Page 1
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.
Zeng J, Nguyen MA, Liu P, da Silva LF, Levesque S, Lin LY, Justus DG, Petri K, Clement K, Porter SN, Verma A, Neri NR, Rosanwo T, Ciuculescu MF, Abriss D, Mintzer E, Maitland SA, Demirci S, Cha HJ, Orkin SH, Tisdale JF, Williams DA, Zhu LJ, Pruett-Miller SM, Pinello L, Joung JK, Pattanayak V, Manis JP, Armant M, Pellin D, Brendel C, Wolfe SA, Bauer DE. Zeng J, et al. Among authors: brendel c. Cell Stem Cell. 2024 Dec 11:S1934-5909(24)00400-4. doi: 10.1016/j.stem.2024.11.001. Online ahead of print. Cell Stem Cell. 2024. PMID: 39672163
Scalable assessment of genome editing off-targets associated with genetic variants.
Lin J, Nguyen MA, Lin LY, Zeng J, Verma A, Neri NR, da Silva LF, Mucci A, Wolfe S, Shaw KL, Clement K, Brendel C, Pinello L, Pellin D, Bauer DE. Lin J, et al. Among authors: brendel c. bioRxiv [Preprint]. 2024 Jul 25:2024.07.24.605019. doi: 10.1101/2024.07.24.605019. bioRxiv. 2024. PMID: 39211178 Free PMC article. Preprint.
Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes.
Windisch R, Soliman S, Hoffmann A, Chen-Wichmann L, Danese A, Vosberg S, Bravo J, Lutz S, Kellner C, Fischer A, Gebhard C, Redondo Monte E, Hartmann L, Schneider S, Beier F, Strobl CD, Weigert O, Peipp M, Schündeln M, Stricker SH, Rehli M, Bernhagen J, Humpe A, Klump H, Brendel C, Krause DS, Greif PA, Wichmann C. Windisch R, et al. Among authors: brendel c. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2312499121. doi: 10.1073/pnas.2312499121. Epub 2024 Jun 10. Proc Natl Acad Sci U S A. 2024. PMID: 38857395 Free PMC article.
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM. De Souza DC, et al. Among authors: brendel c. Nat Commun. 2023 Sep 20;14(1):5850. doi: 10.1038/s41467-023-40923-5. Nat Commun. 2023. PMID: 37730674 Free PMC article.
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.
Casirati G, Cosentino A, Mucci A, Salah Mahmoud M, Ugarte Zabala I, Zeng J, Ficarro SB, Klatt D, Brendel C, Rambaldi A, Ritz J, Marto JA, Pellin D, Bauer DE, Armstrong SA, Genovese P. Casirati G, et al. Among authors: brendel c. Nature. 2023 Sep;621(7978):404-414. doi: 10.1038/s41586-023-06496-5. Epub 2023 Aug 30. Nature. 2023. PMID: 37648862 Free PMC article.
156 results