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Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals.
Sandiego CM, Jin X, Mulnix T, Fowles K, Labaree D, Ropchan J, Huang Y, Cosgrove K, Castner SA, Williams GV, Wells L, Rabiner EA, Carson RE. Sandiego CM, et al. Among authors: wells l. J Nucl Med. 2013 Nov;54(11):1962-8. doi: 10.2967/jnumed.113.122077. Epub 2013 Oct 10. J Nucl Med. 2013. PMID: 24115528 Free PMC article.
Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer's disease patients and control subjects.
Varrone A, Oikonen V, Forsberg A, Joutsa J, Takano A, Solin O, Haaparanta-Solin M, Nag S, Nakao R, Al-Tawil N, Wells LA, Rabiner EA, Valencia R, Schultze-Mosgau M, Thiele A, Vollmer S, Dyrks T, Lehmann L, Heinrich T, Hoffmann A, Nordberg A, Halldin C, Rinne JO. Varrone A, et al. Among authors: wells la. Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):438-46. doi: 10.1007/s00259-014-2955-8. Epub 2014 Nov 21. Eur J Nucl Med Mol Imaging. 2015. PMID: 25412766 Clinical Trial.
Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.
Owen DR, Narayan N, Wells L, Healy L, Smyth E, Rabiner EA, Galloway D, Williams JB, Lehr J, Mandhair H, Peferoen LA, Taylor PC, Amor S, Antel JP, Matthews PM, Moore CS. Owen DR, et al. Among authors: wells l. J Cereb Blood Flow Metab. 2017 Aug;37(8):2679-2690. doi: 10.1177/0271678X17710182. Epub 2017 May 22. J Cereb Blood Flow Metab. 2017. PMID: 28530125 Free PMC article.
Preclinical in vitro and in vivo evaluation of [11C]ORM-13070 as PET ligand for alpha-2C adrenergic receptor occupancy using PET imaging in non-human primates.
Piel I, Constantinescu CC, de la Puente Bethencourt D, Bonsall DR, Rabiner EA, Zasadny KR, Llopis Amenta A, Wells LA, Poethko T, Prange W, Delbeck M. Piel I, et al. Among authors: wells la. J Cereb Blood Flow Metab. 2024 Oct 31:271678X241291949. doi: 10.1177/0271678X241291949. Online ahead of print. J Cereb Blood Flow Metab. 2024. PMID: 39479946 Free PMC article.
Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao WN, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman P, Salem N, Bonsall D, Amaral B, Varlow C, Wells L, Martarello L, Patel S, Liang SH, Kurumbail RG, Haggarty SJ, Scott PJH, Vasdev N. Bernard-Gauthier V, et al. Among authors: wells l. J Med Chem. 2019 Nov 14;62(21):9600-9617. doi: 10.1021/acs.jmedchem.9b01030. Epub 2019 Oct 21. J Med Chem. 2019. PMID: 31535859 Free PMC article.
730 results