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Page 1
Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.
De Leu N, Heremans Y, Coppens V, Van Gassen N, Cai Y, D'Hoker J, Magenheim J, Salpeter S, Swisa A, Khalaileh A, Arnold C, Gradwohl G, Van de Casteele M, Keshet E, Dor Y, Heimberg H. De Leu N, et al. Among authors: gradwohl g. Diabetologia. 2014 Jan;57(1):140-7. doi: 10.1007/s00125-013-3076-9. Diabetologia. 2014. PMID: 24121626
STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage.
De Groef S, Renmans D, Cai Y, Leuckx G, Roels S, Staels W, Gradwohl G, Baeyens L, Heremans Y, Martens GA, De Leu N, Sojoodi M, Van de Casteele M, Heimberg H. De Groef S, et al. Among authors: gradwohl g. Cell Death Dis. 2016 Jun 23;7(6):e2272. doi: 10.1038/cddis.2016.171. Cell Death Dis. 2016. PMID: 27336716 Free PMC article.
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H. Baeyens L, et al. Among authors: gradwohl g. Nat Biotechnol. 2014 Jan;32(1):76-83. doi: 10.1038/nbt.2747. Epub 2013 Nov 17. Nat Biotechnol. 2014. Retraction in: Nat Biotechnol. 2020 Mar;38(3):374. doi: 10.1038/s41587-020-0426-2 PMID: 24240391 Free PMC article. Retracted.
Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD. Hald J, et al. Among authors: gradwohl g. Diabetologia. 2012 Jan;55(1):154-65. doi: 10.1007/s00125-011-2295-1. Epub 2011 Sep 23. Diabetologia. 2012. PMID: 21947380
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H. Mellitzer G, et al. Among authors: gradwohl g. EMBO J. 2006 Mar 22;25(6):1344-52. doi: 10.1038/sj.emboj.7601011. Epub 2006 Mar 2. EMBO J. 2006. PMID: 16511571 Free PMC article.
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Among authors: gradwohl g. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CVE, Van de Casteele M, German MS, Bouwens L, Heimberg H. Baeyens L, et al. Among authors: gradwohl g. Nat Biotechnol. 2020 Mar;38(3):374. doi: 10.1038/s41587-020-0426-2. Nat Biotechnol. 2020. PMID: 32066957 Free PMC article.
Pairing-up SOX to kick-start beta cell genesis.
Grapin-Botton A, Seymour PA, Gradwohl G. Grapin-Botton A, et al. Among authors: gradwohl g. Diabetologia. 2015 May;58(5):859-61. doi: 10.1007/s00125-015-3539-2. Epub 2015 Mar 4. Diabetologia. 2015. PMID: 25733380
89 results