Di WL - Search Results

1

Phase I study protocol for ex-vivo lentiviral gene therapy for the inherited skin disease, Netherton Syndrome.

Di WL, Mellerio JE, Bernadis C, Harper J, Abdul-Wahab A, Ghani S, Martinez-Queipo M, Hara H, McNicol AM, McGrath J, Thrasher AJ, Qasim W. Di WL, et al. Hum Gene Ther Clin Dev. 2013 Oct 18. doi: 10.1089/hum.2013.195. Online ahead of print. Hum Gene Ther Clin Dev. 2013. PMID: 24138501

2

New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI.

Bennett K, Callard R, Heywood W, Harper J, Jayakumar A, Clayman GL, Di WL, Mills K. Bennett K, et al. Among authors: di wl. J Proteome Res. 2010 Aug 6;9(8):4289-94. doi: 10.1021/pr1003467. J Proteome Res. 2010. PMID: 20533828

3

Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome-derived skin grafts.

Di WL, Larcher F, Semenova E, Talbot GE, Harper JI, Del Rio M, Thrasher AJ, Qasim W. Di WL, et al. Mol Ther. 2011 Feb;19(2):408-16. doi: 10.1038/mt.2010.201. Epub 2010 Sep 28. Mol Ther. 2011. PMID: 20877344 Free PMC article.

4

Human involucrin promoter mediates repression-resistant and compartment-specific LEKTI expression.

Di WL, Semenova E, Larcher F, Del Rio M, Harper JI, Thrasher AJ, Qasim W. Di WL, et al. Hum Gene Ther. 2012 Jan;23(1):83-90. doi: 10.1089/hum.2011.091. Hum Gene Ther. 2012. PMID: 21895535 Free PMC article.

5

Inflammatory skin and bowel disease linked to ADAM17 deletion.

Blaydon DC, Biancheri P, Di WL, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F, Toynbee M, Walne A, O'Toole EA, Martin JE, Lindley K, Vulliamy T, Abrams DJ, MacDonald TT, Harper JI, Kelsell DP. Blaydon DC, et al. Among authors: di wl. N Engl J Med. 2011 Oct 20;365(16):1502-8. doi: 10.1056/NEJMoa1100721. N Engl J Med. 2011. PMID: 22010916 Free article.

6

The identification of a new role for LEKTI in the skin: The use of protein 'bait' arrays to detect defective trafficking of dermcidin in the skin of patients with Netherton syndrome.

Bennett K, Heywood W, Di WL, Harper J, Clayman GL, Jayakumar A, Callard R, Mills K. Bennett K, et al. Among authors: di wl. J Proteomics. 2012 Jul 16;75(13):3925-37. doi: 10.1016/j.jprot.2012.04.045. Epub 2012 May 12. J Proteomics. 2012. PMID: 22588119

7

Phase I study protocol for ex vivo lentiviral gene therapy for the inherited skin disease, Netherton syndrome.

Di WL, Mellerio JE, Bernadis C, Harper J, Abdul-Wahab A, Ghani S, Chan L, Martinez-Queipo M, Hara H, McNicol AM, Farzaneh F, McGrath J, Thrasher A, Qasim W. Di WL, et al. Hum Gene Ther Clin Dev. 2013 Dec;24(4):182-90. doi: 10.1089/humc.2013.195. Hum Gene Ther Clin Dev. 2013. PMID: 24329107 Clinical Trial.

8

Lentiviral Engineered Fibroblasts Expressing Codon-Optimized COL7A1 Restore Anchoring Fibrils in RDEB.

Georgiadis C, Syed F, Petrova A, Abdul-Wahab A, Lwin SM, Farzaneh F, Chan L, Ghani S, Fleck RA, Glover L, McMillan JR, Chen M, Thrasher AJ, McGrath JA, Di WL, Qasim W. Georgiadis C, et al. Among authors: di wl. J Invest Dermatol. 2016 Jan;136(1):284-92. doi: 10.1038/JID.2015.364. J Invest Dermatol. 2016. PMID: 26763448 Free PMC article.

9

Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin.

Petrova A, Capalbo A, Jacquet L, Hazelwood-Smith S, Dafou D, Hobbs C, Arno M, Farcomeni A, Devito L, Badraiq H, Simpson M, McGrath JA, Di WL, Cheng JB, Mauro TM, Ilic D. Petrova A, et al. Among authors: di wl. Stem Cells Dev. 2016 Sep 15;25(18):1366-75. doi: 10.1089/scd.2016.0156. Epub 2016 Aug 30. Stem Cells Dev. 2016. PMID: 27460132 Free PMC article.

10

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.

Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SA, Moffatt M, Cookson WO, Harper JI, Di WL, Brown SJ, Reinheckel T, O'Shaughnessy RF. Naeem AS, et al. Among authors: di wl. J Allergy Clin Immunol. 2017 Apr;139(4):1228-1241. doi: 10.1016/j.jaci.2016.09.052. Epub 2016 Nov 29. J Allergy Clin Immunol. 2017. PMID: 27913303 Free PMC article.

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