Coombs GH - Search Results

1

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB.

Schröder J, Noack S, Marhöfer RJ, Mottram JC, Coombs GH, Selzer PM. Schröder J, et al. Among authors: coombs gh. PLoS One. 2013 Oct 16;8(10):e77460. doi: 10.1371/journal.pone.0077460. eCollection 2013. PLoS One. 2013. PMID: 24146999 Free PMC article.

2

Chemical shift assignments of Leishmania mexicana ICP, a novel cysteine peptidase inhibitor.

Smith BO, Westrop GD, Mottram JC, Coombs GH. Smith BO, et al. Among authors: coombs gh. J Biomol NMR. 2006;36 Suppl 1(Suppl 1):7. doi: 10.1007/s10858-005-4739-8. J Biomol NMR. 2006. PMID: 16596344 Free PMC article. No abstract available.

3

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.

Williams RA, Tetley L, Mottram JC, Coombs GH. Williams RA, et al. Among authors: coombs gh. Mol Microbiol. 2006 Aug;61(3):655-74. doi: 10.1111/j.1365-2958.2006.05274.x. Epub 2006 Jun 27. Mol Microbiol. 2006. PMID: 16803590 Free article.

4

α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.

Steert K, Berg M, Mottram JC, Westrop GD, Coombs GH, Cos P, Maes L, Joossens J, Van der Veken P, Haemers A, Augustyns K. Steert K, et al. Among authors: coombs gh. ChemMedChem. 2010 Oct 4;5(10):1734-48. doi: 10.1002/cmdc.201000265. ChemMedChem. 2010. PMID: 20799311 Free PMC article.

5

Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella.

Schaeffer M, Schroeder J, Heckeroth AR, Noack S, Gassel M, Mottram JC, Selzer PM, Coombs GH. Schaeffer M, et al. Among authors: coombs gh. Antimicrob Agents Chemother. 2012 Mar;56(3):1190-201. doi: 10.1128/AAC.05528-11. Epub 2011 Dec 5. Antimicrob Agents Chemother. 2012. PMID: 22143531 Free PMC article.

6

Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease.

Tornøe CW, Sanderson SJ, Mottram JC, Coombs GH, Meldal M. Tornøe CW, et al. Among authors: coombs gh. J Comb Chem. 2004 May-Jun;6(3):312-24. doi: 10.1021/cc020085v. J Comb Chem. 2004. PMID: 15132590

7

Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes.

Juliano MA, Brooks DR, Selzer PM, Pandolfo HL, Judice WA, Juliano L, Meldal M, Sanderson SJ, Mottram JC, Coombs GH. Juliano MA, et al. Among authors: coombs gh. Eur J Biochem. 2004 Sep;271(18):3704-14. doi: 10.1111/j.1432-1033.2004.04311.x. Eur J Biochem. 2004. PMID: 15355348 Free article.

8

Cysteine peptidases as virulence factors of Leishmania.

Mottram JC, Coombs GH, Alexander J. Mottram JC, et al. Among authors: coombs gh. Curr Opin Microbiol. 2004 Aug;7(4):375-81. doi: 10.1016/j.mib.2004.06.010. Curr Opin Microbiol. 2004. PMID: 15358255 Review.

9

The structure of Leishmania mexicana ICP provides evidence for convergent evolution of cysteine peptidase inhibitors.

Smith BO, Picken NC, Westrop GD, Bromek K, Mottram JC, Coombs GH. Smith BO, et al. Among authors: coombs gh. J Biol Chem. 2006 Mar 3;281(9):5821-8. doi: 10.1074/jbc.M510868200. Epub 2005 Dec 28. J Biol Chem. 2006. PMID: 16407198 Free PMC article.

10

Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

Mottram JC, Brooks DR, Coombs GH. Mottram JC, et al. Among authors: coombs gh. Curr Opin Microbiol. 1998 Aug;1(4):455-60. doi: 10.1016/s1369-5274(98)80065-9. Curr Opin Microbiol. 1998. PMID: 10066510 Review.

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