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Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent.
Larsen SD, Connell MA, Cudahy MM, Evans BR, May PD, Meglasson MD, O'Sullivan TJ, Schostarez HJ, Sih JC, Stevens FC, Tanis SP, Tegley CM, Tucker JA, Vaillancourt VA, Vidmar TJ, Watt W, Yu JH. Larsen SD, et al. J Med Chem. 2001 Apr 12;44(8):1217-30. doi: 10.1021/jm000095f. J Med Chem. 2001. PMID: 11312922
Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid.
Vaillancourt VA, Larsen SD, Tanis SP, Burr JE, Connell MA, Cudahy MM, Evans BR, Fisher PV, May PD, Meglasson MD, Robinson DD, Stevens FC, Tucker JA, Vidmar TJ, Yu JH. Vaillancourt VA, et al. Among authors: larsen sd. J Med Chem. 2001 Apr 12;44(8):1231-48. doi: 10.1021/jm000094n. J Med Chem. 2001. PMID: 11312923
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Pfefferkorn JA, Choi C, Song Y, Trivedi BK, Larsen SD, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Sekerke C, Auerbach B, Pavlovsky A, Harris MS, Bainbridge G, Caspers N. Pfefferkorn JA, et al. Among authors: larsen sd. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4531-7. doi: 10.1016/j.bmcl.2007.05.097. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574411
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M. Pfefferkorn JA, et al. Among authors: larsen sd. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4538-44. doi: 10.1016/j.bmcl.2007.05.096. Epub 2007 Jun 6. Bioorg Med Chem Lett. 2007. PMID: 17574412
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD. Pfefferkorn JA, et al. Among authors: larsen sd. J Med Chem. 2008 Jan 10;51(1):31-45. doi: 10.1021/jm070849r. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072721
104 results