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Page 1
Synthesis of selective inhibitors of sphingosine kinase 1.
Baek DJ, MacRitchie N, Pyne NJ, Pyne S, Bittman R. Baek DJ, et al. Among authors: pyne s, pyne nj. Chem Commun (Camb). 2013 Mar 14;49(21):2136-8. doi: 10.1039/c3cc00181d. Epub 2013 Feb 7. Chem Commun (Camb). 2013. PMID: 23388656 Free PMC article.
The role of sphingosine 1-phosphate in inflammation and cancer.
Pyne NJ, Ohotski J, Bittman R, Pyne S. Pyne NJ, et al. Among authors: pyne s. Adv Biol Regul. 2014 Jan;54:121-9. doi: 10.1016/j.jbior.2013.08.005. Epub 2013 Sep 11. Adv Biol Regul. 2014. PMID: 24070975 Free article. Review.
Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.
Evangelisti C, Evangelisti C, Teti G, Chiarini F, Falconi M, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Beak DJ, Bittman R, Pyne S, Pyne NJ, Martelli AM. Evangelisti C, et al. Among authors: pyne s, pyne nj. Oncotarget. 2014 Sep 15;5(17):7886-901. doi: 10.18632/oncotarget.2318. Oncotarget. 2014. PMID: 25226616 Free PMC article.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. Tonelli F, et al. Among authors: pyne s, pyne nj. Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20570726 Free PMC article.
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S. Loveridge C, et al. Among authors: pyne s, pyne nj. J Biol Chem. 2010 Dec 10;285(50):38841-52. doi: 10.1074/jbc.M110.127993. Epub 2010 Oct 6. J Biol Chem. 2010. PMID: 20926375 Free PMC article.
428 results