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Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.
Silber BM, Gever JR, Li Z, Gallardo-Godoy A, Renslo AR, Widjaja K, Irwin JJ, Rao S, Jacobson MP, Ghaemmaghami S, Prusiner SB. Silber BM, et al. Among authors: gever jr. Bioorg Med Chem. 2013 Dec 15;21(24):7999-8012. doi: 10.1016/j.bmc.2013.09.022. Epub 2013 Sep 18. Bioorg Med Chem. 2013. PMID: 24183589 Free PMC article.
2-Aminothiazoles as therapeutic leads for prion diseases.
Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. Gallardo-Godoy A, et al. J Med Chem. 2011 Feb 24;54(4):1010-21. doi: 10.1021/jm101250y. Epub 2011 Jan 19. J Med Chem. 2011. PMID: 21247166 Free PMC article.
Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Silber BM, et al. Among authors: gever jr. Pharm Res. 2013 Apr;30(4):932-50. doi: 10.1007/s11095-012-0912-4. Epub 2013 Feb 16. Pharm Res. 2013. PMID: 23417511 Free PMC article.
Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB. Lu D, et al. Among authors: gever jr. J Pharmacol Exp Ther. 2013 Nov;347(2):325-38. doi: 10.1124/jpet.113.205799. Epub 2013 Aug 21. J Pharmacol Exp Ther. 2013. PMID: 23965382 Free PMC article.
31 results