Ke AB - Search Results

1

Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.

Higgins JW, Bao JQ, Ke AB, Manro JR, Fallon JK, Smith PC, Zamek-Gliszczynski MJ. Higgins JW, et al. Among authors: ke ab. Drug Metab Dispos. 2014 Jan;42(1):182-92. doi: 10.1124/dmd.113.054783. Epub 2013 Nov 5. Drug Metab Dispos. 2014. PMID: 24194513

2

Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk.

Zamek-Gliszczynski MJ, Mohutsky MA, Rehmel JL, Ke AB. Zamek-Gliszczynski MJ, et al. Among authors: ke ab. Drug Metab Dispos. 2014 Jun;42(6):1008-15. doi: 10.1124/dmd.114.057018. Epub 2014 Mar 21. Drug Metab Dispos. 2014. PMID: 24658455

3

Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.

Higgins JW, Ke AB, Zamek-Gliszczynski MJ. Higgins JW, et al. Among authors: ke ab. Drug Metab Dispos. 2014 Nov;42(11):1780-4. doi: 10.1124/dmd.114.058784. Epub 2014 Aug 8. Drug Metab Dispos. 2014. PMID: 25106415

4

Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies.

Ke AB, Zamek-Gliszczynski MJ, Higgins JW, Hall SD. Ke AB, et al. Clin Pharmacol Ther. 2014 May;95(5):473-6. doi: 10.1038/clpt.2014.41. Clin Pharmacol Ther. 2014. PMID: 24747234

5

Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.

Xie F, Ke AB, Bowers GD, Zamek-Gliszczynski MJ. Xie F, et al. Among authors: ke ab. J Pharmacol Exp Ther. 2015 Aug;354(2):225-9. doi: 10.1124/jpet.115.225698. Epub 2015 Jun 10. J Pharmacol Exp Ther. 2015. PMID: 26062557

6

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.

Ke AB, Nallani SC, Zhao P, Rostami-Hodjegan A, Isoherranen N, Unadkat JD. Ke AB, et al. Drug Metab Dispos. 2013 Apr;41(4):801-13. doi: 10.1124/dmd.112.050161. Epub 2013 Jan 25. Drug Metab Dispos. 2013. PMID: 23355638 Free PMC article.

7

Pharmacometrics in pregnancy: An unmet need.

Ke AB, Rostami-Hodjegan A, Zhao P, Unadkat JD. Ke AB, et al. Annu Rev Pharmacol Toxicol. 2014;54:53-69. doi: 10.1146/annurev-pharmtox-011613-140009. Annu Rev Pharmacol Toxicol. 2014. PMID: 24392692 Review.

8

Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.

Small DS, Ke AB, Hall SD, Mantlo N, Rotelli M, Friedrich S. Small DS, et al. Among authors: ke ab. J Clin Pharmacol. 2015 Jul;55(7):757-67. doi: 10.1002/jcph.472. Epub 2015 Feb 20. J Clin Pharmacol. 2015. PMID: 25651523

9

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis.

Gupta N, Hanley MJ, Venkatakrishnan K, Bessudo A, Rasco DW, Sharma S, O'Neil BH, Wang B, Liu G, Ke A, Patel C, Rowland Yeo K, Xia C, Zhang X, Esseltine DL, Nemunaitis J. Gupta N, et al. J Clin Pharmacol. 2018 Feb;58(2):180-192. doi: 10.1002/jcph.988. Epub 2017 Aug 11. J Clin Pharmacol. 2018. PMID: 28800141 Free PMC article. Clinical Trial.

10

Physiologically based pharmacokinetic modeling and simulation to predict drug-drug interactions of ivosidenib with CYP3A perpetrators in patients with acute myeloid leukemia.

Prakash C, Fan B, Ke A, Le K, Yang H. Prakash C, et al. Cancer Chemother Pharmacol. 2020 Nov;86(5):619-632. doi: 10.1007/s00280-020-04148-3. Epub 2020 Sep 25. Cancer Chemother Pharmacol. 2020. PMID: 32978634

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