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Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
Talamas FX, Abbot SC, Anand S, Brameld KA, Carter DS, Chen J, Davis D, de Vicente J, Fung AD, Gong L, Harris SF, Inbar P, Labadie SS, Lee EK, Lemoine R, Le Pogam S, Leveque V, Li J, McIntosh J, Nájera I, Park J, Railkar A, Rajyaguru S, Sangi M, Schoenfeld RC, Staben LR, Tan Y, Taygerly JP, Villaseñor AG, Weller PE. Talamas FX, et al. Among authors: davis d. J Med Chem. 2014 Mar 13;57(5):1914-31. doi: 10.1021/jm401329s. Epub 2013 Nov 6. J Med Chem. 2014. PMID: 24195700 Free PMC article.
Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.
Lou Y, Han X, Kuglstatter A, Kondru RK, Sweeney ZK, Soth M, McIntosh J, Litman R, Suh J, Kocer B, Davis D, Park J, Frauchiger S, Dewdney N, Zecic H, Taygerly JP, Sarma K, Hong J, Hill RJ, Gabriel T, Goldstein DM, Owens TD. Lou Y, et al. Among authors: davis d. J Med Chem. 2015 Jan 8;58(1):512-6. doi: 10.1021/jm500305p. Epub 2014 Apr 16. J Med Chem. 2015. PMID: 24712864
Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.
Lou Y, Sweeney ZK, Kuglstatter A, Davis D, Goldstein DM, Han X, Hong J, Kocer B, Kondru RK, Litman R, McIntosh J, Sarma K, Suh J, Taygerly J, Owens TD. Lou Y, et al. Among authors: davis d. Bioorg Med Chem Lett. 2015 Jan 15;25(2):367-71. doi: 10.1016/j.bmcl.2014.11.030. Epub 2014 Nov 20. Bioorg Med Chem Lett. 2015. PMID: 25466710
Novel analogs of tricyclic psychopharmacological agents.
Eichstadt KE, Reepmeyer JC, Cook RB, Riley PG, Davis DP, Wiley RA. Eichstadt KE, et al. Among authors: davis dp. J Med Chem. 1976 Jan;19(1):47-51. doi: 10.1021/jm00223a010. J Med Chem. 1976. PMID: 1246052
Pediatric erythromelalgia from multidisciplinary perspectives: a scoping review.
Ocay DD, Graziano Maloney M, D'Souza G, Brownstein CA, Clinch J, Davis DM, De Ranieri D, Donado C, Halpin M, Kattail D, Lee BH, Lobo K, Ravetti D, Sandroni P, Stinson JN, Tham SW, Walco GA, Walker SM, Yu TW, Berde CB. Ocay DD, et al. Among authors: davis dm. Pediatr Res. 2025 Jan 16. doi: 10.1038/s41390-025-03817-4. Online ahead of print. Pediatr Res. 2025. PMID: 39821136 Review.
5,272 results